摘要
目的 :探讨过氧化物酶体增殖物激活受体α(PPARα)基因第 5外显子L16 2V(CTT→GTT)多态性与 2型糖尿病 (T2DM )的关系。方法 :采用多聚酶联反应 限制性片段长度多态性 (PCR RFLP)的方法对湖北地区 10 0例T2DM患者及 80例正常对照者PPARα基因L16 2V多态性进行研究。结果 :在T2DM患者和正常对照者中未发现PPARα基因L16 2V变异。结论 :PPARα基因L16 2V多态性与湖北地区T2DM不相关。
Objective: To investigate the peroxisome proliferator-activated receptor- α (PPAR α ) gene L162V(CTT→GTT) polymorphism and its relationship with type 2 diabetes mellitus(T2DM). Methods: PPAR α gene L162V polymorphism was assayed by polymerase chain reaction(PCR)-restriction fragment length polymorphism (RFLP) between 100 T2DM and 80 controls in Hubei . Results: Both in T2DM group and control group,PPAR α gene L162V polymorphism was not detected. Conclusion: The results suggest that the L162V polymorphism of PPAR α gene is not associated with T2DM in Hubei population.
出处
《武汉大学学报（医学版）》
CAS
2004年第4期459-461,共3页
Medical Journal of Wuhan University
基金
湖北省自然科学基金资助项目 (2 0 0 2AB14 3 )
