摘要
目的 :研究荔枝核对乙型肝炎病毒的抑制作用及其有效部位。方法 :应用HepG 2 .2 .15细胞系培养系统检测荔枝核提取物A、B、C、D、E、F对HBsAg与HbeAg表达的影响。 结果 :荔枝核提取物A、B、C、D、E、F (2 0 0 ,10 0mg·L-1)对HBsAg和HbeAg表达均有抑制作用 ,其中E成分作用最强 ,在 2 0 0mg·L-1的浓度下 ,于实验第 3天对HBsAg的抑制率为 5 0 % ,对HBeAg的抑制率为 2 0 % ,于实验第 9天对HBsAg的抑制率为90 .9% ,对HBeAg的抑制率为84 .3% (与对照组比较P <0 .0 1)。结论 :荔枝核提取物体外有较强的抗乙肝病毒作用。
OBJECTIVE To investigate the active parts of the extracts of the core of Litchi and their effect on the HBV. METHODS HepG 2.215 cell culture system was used for study of the expressions of HBsAg and HBeAg with A、B、C、D、E、F of the extract components from the core of litchi. RESULTS All extracts A、B、C、D、E 、F (200,100 mg·L -1) of the core of litchi. Were shown to inhibit the expression of HBsAg and HBeAg in HepG 2.2.15 cells, among which the extract E was the most effective, at 200 mg·L -1 in the medium, HBsAg expression was inhibited by 50%, and HBeAg by 20% in the third day of the experiment, and in the 9 th day, the HBsAg was inhibited by 90.9%, the HBeAg by 84.3%(P< 0.01, compared to the control group). CONCLUSION The extracts of the core of litchi are very effective in inhibition of HBV in vitro.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2004年第7期393-395,共3页
Chinese Journal of Hospital Pharmacy
基金
广西科学基金项目 (编号 :0 13 5 0 3 3 )
广西科学研究与技术开发计划项目 (编号 :0 3 3 0 0 15 -4C)
