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盐酸西替利嗪-β-环糊精包合物口腔速溶片的研制 被引量:4

Preparation of fast dissolving tablet containing cetirizine-β-CD inclusion complex
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摘要 目的 :采用普通制片技术 ,制备盐酸西替利嗪 β 环糊精包合物口腔速溶片。 方法 :以颗粒流动性及可压性、崩解时限为指标 ,采用正交设计试验 ,对处方进行优选。结果 :按优化处方制备的口腔速溶片硬度为 3kg的样品崩解时间为 2 0s,在口腔中 30s内崩解。结论 :优化处方的西替利嗪 β OBJECTIVE To prepare fast dissolving tablet containing Cet-β-CD inclusion complex using common compression method. METHODS The formulae were optimized by orthogonal design test in terms of disintegrating time and the flow behavior of granules. RESULTS The disintegrating time of the optimized fast dissolving tablet with 3 kg in hardness was about 20 s econds, and they could disintegrate in the mouth within 30 seconds. CONCLUSION The in-vitro dissolubility of the optimized fast dissolving tablet is better than that of common tablet.
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2004年第7期417-419,共3页 Chinese Journal of Hospital Pharmacy
关键词 盐酸西替利嗪 Β-环糊精 包合物 口腔速溶片 正交试验 Cetirizine hydrochloride β-cyclodextrin inclusion complex fast dissolving tablet orthogonal test
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