摘要
目的通过对血清中Ⅳ型胶原(Ⅳ鄄C)、层粘蛋白(LN)、纤维连接蛋白(FN)和Ⅲ型前胶原(PC鄄Ⅲ)的联合检测,了解砷中毒患者细胞外基质成分的变化,探讨其在砷中毒疾病诊治中的临床意义及可能的发病机制。方法将病区有砷煤接触史,并有慢性砷中毒症状的患者分为轻、中、重度3个实验组,检测血清Ⅳ鄄C、LN、FN和PC鄄Ⅲ,检测结果在各中毒组间比较,同时各实验组再与正常组进行比较。结果轻、中、重度3个实验组的PC鄄Ⅲ水平均高于对照组;中、重度组的Ⅳ鄄C、LN也较对照组高,经统计学处理差异均有显著意义(P<0.05,P<0.01);中、重度组的FN则显著低于对照组(P<0.05);轻度组的Ⅳ鄄C、LN、FN与对照组比较均有增高或降低趋势,但差异无显著意义(P>0.05)。结论煤砷慢性中毒患者细胞外基质的主要成分合成降解失衡,胶原在细胞内大量沉积,导致机体主要脏器功能障碍,这可能是砷中毒的发病机制之一;细胞外基质成分的检测对砷中毒病程发生发展及疗效均有重要意义。
Objective To measure Ⅳ-collagen(Ⅳ-C),laminin(LN), fibronectin(FN), precollagen-Ⅲ( PC-Ⅲ) and confirm the clinical significance of intra cellular matrix among arsenism patients. Methods The patients were divide into three groups. The serum contents of Ⅳ-C, LN, FN and PC-Ⅲ were measured and analysed. Results Compared with control group, the contents of Ⅳ-C, LN, PC-Ⅲ were higher in moderate and serious groups. There was marked difference, between the moderate, serious groups and control group(P < 0.05,P < 0.01). The contents of FN were lower(P < 0.05). The Ⅳ-C, LN, FN in silght poisoning were low-grade increase and decrease. There was no obvious difference between the mild and control groups(P > 0.05). Conclusions They play an important part of the above-mentioned four materials in patients with coal type arsenic poisoning. It has important clinical significance to measure the extra cellular matrix (ECM) among arsenism patients .
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2004年第4期373-374,共2页
Chinese Jouranl of Endemiology
基金
全军医学科研"十五"计划面上基金A类资助项目(01MA048)
