血液动力学在血管重构中的作用被引量：9

Hemodynamics and vascular remodeling

下载PDF

导出

摘要血液动力学主要是应用流体力学理论和方法研究血液流动、血管生理和病理之间关系的一门边缘性学科。近年来国内外学者认为血液动力学因素对血管重构有着重要的影响 ,当血液动力学发生改变后 ,血管内皮细胞通过跨膜蛋白、信号传导和基因表达等将力学信息传递到细胞内 ,再经过效应分子将转导信号最终作用于相应的血管 ,从而参与血管形态和功能的重构过程。本文旨在简述血液在流动过程中 ,血液动力学因素对血管内皮细胞的形态和功能、平滑肌细胞增殖和细胞外基质的生成等的影响。 Hemodynamic forces play an active role in many physiological and pathophysiological processes of the cardiovascular system. Vascular remodeling, changes of structure, geometry and mechanical properties of the artery, plays a role in many (patho)physiological processes. Several lines of evidence support a role for hemodynamic forces in the development and progression of vascular cell, such as endothelial cell, vascular smooth muscle cell and extracellular matrix. This review focuses on the role of hemodynamic forces in vascular remodeling relevant to vascular diseases. Cellular signal involves a complex interplay between cytoskeletal and biochemical elements and results in changes in G proteins, signal transduction and gene expression. We review current knowledge on flow-induced vascular remodeling and summarize the molecular mechanisms believed responsible for endothelial cell gene regulation with an emphasis on signal transduction.

作者王桂清

机构地区上海市脑血管病防治研究所

出处《基础医学与临床》 CSCD 北大核心 2004年第3期264-268,共5页 Basic and Clinical Medicine

关键词血液动力学血管重构内皮功能信号转导基因 hemodynamics vascular remodeling endothelial function signal transduction gene

分类号 R363 [医药卫生—病理学]

引文网络
相关文献

参考文献28

1Lovett JK, Rothwell PM. Site of carotid plaque ulceration in relation to direction of blood flow: an angiographic and pathological study[J]. Cerebrovasc Dis, 2003, 16(4): 369-375.
2Fung YC, Liu SQ. Elementary mechanics of the endothelium of blood vessels. J Biomech Eng [J]. 1993; 115(1):1-12.
3Schmid-Schoenbein GW, Fung YC, Zweifach BW. Vascular endothelium-leukocyte interaction; sticking shear force in venules[J]. Circ Res, 1975, 36(1):173-84.
4Jalil JE, Janicki JS, Pick R, et al. Coronary vascular remodeling and myocardial fibrosis in the rat with renovascular hypertension. Response to captopril[J]. Am J Hypertens, 1991, 4(1 Pt 1):51-55.
5Ameshima S, Golpon H, Cool CD, et al. Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth[J]. Circ Res, 2003, 92(10): 1162-1169.
6王桂清,杨永举,王艳,俞学海,郭吉平,王素春,钱国正.脑血管血液动力学指标检测参数的参考值[J].中华流行病学杂志,2003,24(2):98-101. 被引量：20
7Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis[J]. JAMA, 1999, 282(21):2035-2042.
8Chiu JJ, Chen LJ, Chen CN, et al. A model for studying the effect of shear stress on interactions between vascular endothelial cells and smooth muscle cells[J]. J Biomech, 2004 ,37(4):531-539.
9Butler PJ, Norwich G, Weinbaum S, et al. Shear stress induces a time- and position-dependent increase in endothelial cell membrane fluidity[J]. Am J Physiol Cell Physiol, 2001,280(4):C962-C969.
10Nerem RM, Harrison DG, Taylor WR, Alexander RW. Hemodynamics and vascular endothelial biology[J] . J Cardiovasc Pharmacol, 1993, 21(Suppl1):S6-10.