摘要
目的 :观察醒脑静注射液对急性脑出血患者外周血中炎症细胞因子水平的影响。方法 :将 70例急性脑出血患者随机分为醒脑静注射液治疗组和胞二磷胆碱注射液对照组 ,每组 35例。采用放射免疫法测定各组患者治疗前后血中肿瘤坏死因子 α(TNFα)、白细胞介素 1(IL 1)、IL 6水平 ,并与 2 0例正常人进行对照。结果 :两组急性脑出血患者血浆 TNFα、IL 1、IL 6的水平均明显高于正常对照组 (P均 <0 .0 5 )。使用醒脑静注射液治疗后 ,血浆 TNFα、IL 1水平均明显下降 ,下降程度也明显高于胞二磷胆碱治疗对照组(P均 <0 .0 5 ) ;IL 6的水平虽有下降 ,但两治疗组间无显著差异。结论 :醒脑静注射液较胞二磷胆碱更能显著抑制炎症细胞因子的释放 ,降低细胞因子的水平。
Objective: To investigate the therapeutic effects of Xingnaojing injection(醒脑静注射液) on serum levels of inflammatory cytokines in acute intracerebral hemorrhagic patients. Methods: Seventy patients were randomly divided into two groups: the Xingnaojing injection treatment group (treatment group, n=35) and the citicoline injection treatment group (control group, (n=35)). Tumor necrosis factorα(TNFα), (interleukin1)(IL1) and IL6 were analyzed by radioimmunoassay before and after the treatment. (Twenty) healthy people were as normal control. Results: The serum levels of TNFα, IL1, IL6 in both (treatment) groups were higher than those of normal control group(all P<0.05). Xingnaojing injection (could) (decreased) TNFα and IL1 levels significantly, and the decreasing extent was greater than that of the (citicoline) (treatment) group(all P<0.05). Both Xingnaojing and citicoline treatment could decrease the serum level of (IL6), but there was not any difference between the two groups. Conclusion: Xingnaojing injection can (inhibit) (releasing) of inflammatory cytokines and decrease cytokines levels more effectively than citicoline.
出处
《中国中西医结合急救杂志》
CAS
2004年第4期224-226,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
广东省广州市中医药
中西医结合科研课题基金资助项目(200227)
关键词
脑出血
急性
肿瘤坏死因子
白细胞介素
中医药治疗
acute intracerebral hemorrhage
tumor necrosis factor
interleukin
traditional Chinese medicine therapy
