摘要
目的:系统观察清肺凉血法(清肺祛脂方)对寻常痤疮的临床疗效和机制。方法:将120例痤疮患者随机分成两组,治疗组(清肺凉血法)60例,对照组(异维A酸)60例,观察治疗前后的痤疮各种皮肤损害(白头粉刺、黑头粉刺、炎症丘疹、脓疱)、皮脂溢出率、血清游离脂肪酸以及临床疗效评价。结果:清肺凉血法对痤疮患者皮损有明显的改善(u=9.6,3.80,13.96,14.32,P<0.05),并减少皮脂溢出率(u=6.25,12,P<0.05)、降低血清游离脂肪酸(t=5.24,2.09,P<0.05),临床总有效率达90%,与阳性对照西药相近。结论:清肺凉血法(清肺祛脂方)对寻常痤疮临床疗效确切,皮脂溢出率及降低血清游离脂肪酸是其作用机制之一。
AIM:To verify the clinical effect and curative mechanism of Qingfei Liangxue Fa(prescription for clearing lung and removing fat) in the treatment of acne vulgaris. METHODS:One hundred and twenty patients with acne vulgaris were randomly divided into treatment(treated with Qingfei Liangxue Fa) group and control group(treated with isotretinoin),with 60 patients in each group.The lesions of skin in acne patients,including whiteheads,blackheads,inflammatory papules and pustules,were observed,the sebum excretion rate(SER) and levels of free fatty acid(FFA) were measured,and the clinical effects were evaluated. RESULTS:The Qingfei Qingliang Fa improved the lesions of skin obviously(u=9.6,3.80,13.96,14.32,P< 0.05),decreased the SER(u=6.25,12,P< 0.05),and reduced the levels of FFA(t=5.24,2.09,P< 0.05).The total effective rate was 90% in the treatment group,similar to that in the control group. CONCLUSION:Qingfei Liangxue Fa is a good prescription for acne vulgaris with obvious effect.The control of SER and FFA is one of its therapeutic mechanisms.
出处
《中国临床康复》
CSCD
2004年第20期4056-4057,共2页
Chinese Journal of Clinical Rehabilitation
基金
上海市卫生局科研基金资助项目(98Z006)~~
