摘要
目的 :探讨ESHAP方案对难治性或复发性恶性淋巴瘤 (Malignantlymphoma,ML)的疗效。方法 :采用ESHAP方案治疗 36例难治性或复发性恶性淋巴瘤 ,其中难治性非霍奇金淋巴瘤 (NHL) 17例 ,复发NHL16例 ,难治性或复发性霍奇金淋巴瘤 (HL) 3例。结果 :12例难治性或复发性ML患者达完全缓解 (CR率为 33.3% ) ,10例达部分缓解 (PR率为 2 7.8% ) ;总有效率为 6 1.1% ,其中生存最长者 4 3个月 ,仍处于CR期。毒副作用主要为消化道症状、轻度肝功能异常以及骨髓抑制。结论 :ESHAP方案对部分难治性或复发性ML患者仍有效 ,毒副作用可以耐受。可用于治疗对其他化疗方案无效的难治性或复发性ML。
Objective:To evaluate the effects of ESHAP regimen in treatment of refractory and relapsing lymphoma.Method:36 patients with refractory or relapsing malignant lymphoma (17 refractory Non-Hodgkin's lymphoma patients,16 relapsing NHL patients,3 refractory/ relapsing Hodgkin's lymphoma patients)were treated with ESHAP regimen.Result:The rate of complete remission was 33.3%(12/36) , the rate of partial remission was 27.8%(10/36) ,and the overall response rate was 61.1%.Main toxicities were gastrointestinal side effects,myelosuppression and neutropenia.Conclusion:ESHAP regimen could be employed in treatment of the patients with refractory or relapsing malignant lymphoma who did not respond to other regimen, and the regiment was safe.
出处
《临床血液学杂志》
CAS
2004年第4期187-188,共2页
Journal of Clinical Hematology
关键词
淋巴瘤
化疗
ESHAP方案
疗效
Malignant lymphoma
Chemotherapy
ESHAP regimen
Outcome
