摘要
目的探讨近20年来大肠癌发病部位的变化趋势。方法筛选1984～1989年及1997年～2002年两个时间段国内公开发表的医学论文,按时间阶段分为两组,总计报告7056例大肠癌病例。对其报告的病例资料分别进行统计,然后对比分析大肠癌在发病部位、年龄、性别、分期、病理类型几方面的变化情况。结果 (1)直肠癌所占比例由80年代组的65.27%下降到近年组的52.94%,结肠癌所占比例由34.73%升至47.06%,结果有显著性差异,P<0.001。而其中近侧结肠癌所占比例由19.63%升至29.16%,有显著差异,P<0.001%。(2)发病年龄高峰后移,中位发病年龄由50岁上升至57岁。(3)两组患者性别构成及病理类型构成无明显差异,P>0.05。(4)近年组Dukes A期病例所占比例明显高于80年代组,分别为20.61%、5.60%有显著性差异,P<0.001。结论大肠癌的发病部位仍以直肠、乙状结肠为主,但肿瘤的解剖分布明显向近侧迁移;大肠癌发病高峰年龄后移;大肠癌患者的性别构成及病理类型构成无明显的变化;大肠癌早期患者的检出率增加,病理分期提前。
Objective To study the variation trend of localization of colorectal cancer in recent 20 yeats.Methods analyze the published medical theses in 1984 to 1989,and 1997 to 2002.All the total 7056 colorectal cancer cases were divided into two groups.The data of the two groups were analyzed respectively in localization,age,gender,stage and pathological type.Results (1)The proportioa of rectal cancer in 1980s was descend from 65.27% to 52.94% in 1990s,while the proportion of colonic cancer rised from 34.73% to 47.06% with the significant statistic difference,P<0.001.The proportion of rostral colonic cancer rised from 19.63%to 29.16% with the significant statistic differencee,P <0.001.(2)the incident top of age was delayed,the medial incident age rised from 50 to 57 years old.(3)The ingredient of gender and patholpgieal type of the two grpups had no significant difference,P>0.05.(4)The proportion of Dukes A stage in 1990s group was higher maekedly than 1980s group,they are 20.61% and 5.6% respectively with significant statistic difference,P<0.001.Conclusion rectum and sigmoid were still the main localizations of colorectal cancer,but the anatomical position of the tumors was maekedly moved rostrlly;the incident age was delayed;the ingredient of gender and pathological type of the two groups had no significant difference;the detection percent of colorectal cancer of early stage was increased,pathological stage was moved ahead.
出处
《医学研究通讯》
2004年第7期45-47,共3页
Bulletin of Medical Research
