摘要
锌指基因家族是人体中最大的基因家族,它参与细胞分化、胚胎发育,并与许多疾病的发生相关.根据半胱氨酸(C)和组氨酸(H)的数目和位置可将锌指蛋白分为C2H2、C2HC、C2C2、C2HCC2C2、C2C2C2C2等亚类.C2H2型锌指是最普遍的类型,它们作为重要的转录调控因子参与许多的生理过程.C2H2型锌指蛋白包含的锌指数目从1个到30多个不等.依据锌指的数量以及在蛋白中的分布情况,大多数C2H2型锌指蛋白属于下列3类之一:1)含3个C2H2锌指的蛋白(tC2H2);2)含多个锌指的C2H2型锌指结构蛋白(maC2H2);3)锌指成对间隔排列的C2H2型锌指蛋白(spC2H2).一些C2H2型锌指蛋白能识别并结合特异性RNA或DNA片段,另一些则只能与RNA结合.通常锌指蛋白含锌指数目越多,它选择结合的能力就越强.
Zinc finger gene family is the largest one of human gene families and involved in cell differentiation, embryo genesis and disease generation. It could be divided into several types of zinc finger proteins ,such as C2H2、C2HC、C2C2、C2HCC2C2、C2C2C2C2 etc, based on numbers and positions Cys and His residues. The most common zinc finger gene type is the C2H2 type, which plays an important role in many physiological processes as transcriptional regulators. Zinc finger proteins contain from 1 to more than 30 figures. Based on the number and the pattern of the fingers, most of the C2H2 finger proteins will be divided into one of three groups: triple C2H2, multiple adjacent C2H2, and separated paired C2H2 finger proteins. Some C2H2 finger proteins can bind to RNA or protein in addition to DNA, and others bind to RNA alone. In general,the greater the number of fingers, the more fingers with specific affinity for different ligands.
出处
《生命科学研究》
CAS
CSCD
2004年第3期215-220,共6页
Life Science Research
基金
湖南师范大学校内自然科学基金资助项目(24040616)
