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“分子开关”MAT1基因的研究进展 被引量：4

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摘要 MAT1作为三聚体CAK激酶的重要组成部分 ,对CAK的活性起着“分子开关”的作用 ,因而在调节信号分子转导、控制细胞周期的进程、影响细胞的增殖和凋亡等方面起着关键作用。作为肿瘤相关基因 ,MAT1是肿瘤基因治疗靶目标中值得期待的一个突破口。
作者 刘建平 袁世珍
机构地区 中山大学附属第二医院消化内科
出处 《国外医学（生理病理科学与临床分册）》 2004年第4期306-308,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 细胞周期素依赖性蛋白激酶 CDK激活激酶 MAT1 细胞周期
分类号 R346 [医药卫生—基础医学]
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参考文献20

  • 1Kaldis P. The cdk-activating kinase ( CAK ) : from yeast to mammals[J]. Cell Mol Life Sci, 1999, 55(2) :284-296.
  • 2Eki T, Okumura K, Abe M, et al. Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 ( MNAT1 ) to chromosome bands 5q13.3-q14 and 14q23, respectively [ J ]. Genomics, 1998, 47 ( 1 ) : 115-120.
  • 3Kaldis P, Russo AA, Chou HS, et al. Human and yeast cdk-actirating kinases (CAKs) display distinct substrate specificities [ J ].Mol Biol Cell, 1998, 9(9) :2545-2560.
  • 4Tsakraklides V. Solomon MJ. Comparison of Cakl p-like cyelin-dependent kinase-activating kinases [ J ]. J Biol Chem, 2002, 277(36) :33482-33489.
  • 5Bochar DA, Pan ZQ, Knights R, et al. Inhibition of transcription by the trimeric cyclin-dependent kinase 7 complex [ J ]. J Biol Chem, 1999, 274(19) :13162 -13166.
  • 6Tsukamoto T, Yoo J, Hwang SI, et al. Nandi S. Expression of MAT1/PEA-15 mRNA isoforms during physiological and neoplastic changes in the mouse mammary gland[ J ]. Cancer Lett, 2000,149(1-2) :105-113.
  • 7Yee A, Nichols MA, Wu L, et al. Molecular cloning of CDKT-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor[J]. Cancer Res, 1995,55 (24):6058-6062.
  • 8Wu L, Chen P, Hwang JJ, et al. RNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cells[J]. J Biol Chem, 1999, 274(9) :5564-5572.
  • 9Gervais V, Busso D, Wasielewski E, et al. Solution structure of the N-terminal domain of the human TFIlH MAT1 subunit: new insights into the RING finger family[J]. J Biol Chem, 2001,276(10) :7457-7464.
  • 10Busso D, Keriel A, Sandrock B, et al. Distinct regions of MATI regulate cdk7 kinase and TFIIH transcription activities [ J ]. J Biol Chem, 2000,275 ( 30 ) :22815 -22823.

同被引文献44

  • 1刘建平,袁世珍,张世能,詹俊,朱兆华.胰腺癌中MAT1蛋白的表达与其临床病理特征的关系[J].中国病理生理杂志,2005,21(1):163-166. 被引量：6
  • 2张世能,徐凤琴,黄志清,曾志勇,袁世珍.反义MAT1重组腺病毒对人胰腺癌细胞BxPC-3的周期调控作用[J].中华医学杂志,2005,85(19):1348-1351. 被引量：9
  • 3Zamore PD, Tuschl T, Sharp PA, et al. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell,2000, 101 : 25-33.
  • 4Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21- nucleotide RNAs mediates RNA interference in cultured mammalian cells. Nature ,2001,411 : 494--498.
  • 5Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 1998, 391 : 806-811.
  • 6Harborth J, Elbashir SM, Bechert K, et al. Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci, 2001, 114(Pt 24) : 4557-4565.
  • 7Svoboda P, Stein P, Hayashi H, et al. Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference. Development, 2000, 127 : 4147-4156.
  • 8Rossi DJ, Londesborough A, Korsisaari N, et al. Inability to enter S phase and defective RNA polymerase Ⅱ CTD phosphorylation in mice lacking Matl. EMBO J, 2001,20: 2844-2856.
  • 9Wu L, Chen P, Shum CH, et al. MAT1-modulated CAK activity regulates cell cycle G (1) exit. Mol Cell Biol, 2001, 21: 260-270.
  • 10Zhang S, He Q, Peng H, et al. MATl-modulated cyclindependent kinase-activating kinase activity cross-regulates neuroblastoma cell G1 arrest and neurite outgrowth. Cancer Res, 2004, 64: 2977-2983.

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国外医学（生理病理科学与临床分册）
2004年 第4期

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