摘要
目的 :观察兔烫伤早期多器官功能不全综合征(MODS)发生后动脉壁亮氨酸脑啡肽 (L Enk)含量的变化 ,研究烫伤早期MODS时动脉壁L Enk在血流动力学改变中的作用及阿片受体拮抗剂纳洛酮对MODS的治疗作用 .方法 :通过制备兔烫伤早期MODS模型 ,检测假烫组 (SB)、烫伤组 (B)、烫伤纳洛酮治疗组在烫伤后 4 8h的平均动脉血压、中心静脉压、心输出量 ;计算总外周阻力、心指数 ;测定血清肌酸磷酸激酶 (CK)、谷丙转氨酶 (GPT)、尿素氮 (BUN)、肌酐 (Cr)、血小板(PLT)等反映心、肝、肾、血液功能的一系列指标 .放免分析法测定动脉壁L Enk的含量 .结果 :①与SB相比 ,烫伤早期MODS发生后兔肠系膜动脉、肾动脉、肺动脉L Enk含量均明显降低 (P <0 .0 1 ) .②与烫伤组相比 ,烫伤纳洛酮治疗组CK ,GPT ,Cr,PLT无明显改变 ,BUN明显降低 .结论 :烫伤后 4 8h肠系膜动脉、肾动脉、肺动脉L Enk含量下降可能是微血管痉挛收缩 ,全身血管阻力增高 。
AIM: To observe the changes of leucine enkephalin (L Enk) content in the arteries of rabbits in early stage after burn and to study the effects of L Enk in the arteries on the hemodynamics changes at early stage following burns. METHODS: The rabbits were divided into 3 groups, the sham burn group (SB), burn group (B), and burn and Naloxone therapy group (BN). The mean arterial pressure (MAP), central venous pressure (CVP) and cardiac output (CO) were monitored and the systemic vascular resistance (SVR) and cardiac index (CI) were calculated. The levels of serum creatine phosphokinase (CK), glutamic pyruvic transaminase (GPT), blood urea nitrogen (BUN), creatinine (Cr), blood platelet count (PLT) and HB were detected. RESULTS: ① In comparison with those in SB, the L Enk contents of mesenteric artery, renal artery and pulmonary artery decreased significantly in group B. ② In comparison with those in group B, the CK, GPT and BUN did not change markedly in BN group. CONCLUSION: The decreasing of L Enk contents in arteries may be responsible for the contraction of microvessels, the increase of SVR, and the damage of organ functions.
出处
《第四军医大学学报》
北大核心
2004年第13期1162-1164,共3页
Journal of the Fourth Military Medical University
基金
军队医药卫生科研基金 (96D0 4 4 )
