摘要
目的 了解IL 6基因启动子区域 174位点G/C多态性对原发性胆汁性肝硬化 (Primarybiliarycirrhosis ,PBC)的影响。方法 用序列特异性PCR(SequencespecificPCR ,SSP)方法检测 15 4例正常人及 6 4例PBC患者。结果 15 4例正常人基因型全部为GG ,6 4例PBC患者有 2例基因型为GC ,其余 6 2例全部为GG型。统计学分析结果PBC患者基因表型与正常人显著不同 (χ2 =4 .86 ,P <0 0 5 )。结论 IL 6启动子区域 174位点G/C多态性可能与PBC存在基因连锁 。
Objective To study the influence of G/C polymorphism of IL-6 gene at site-174 on primary biliary cirrhosis(PBC). Methods Sequence specific PCR was used in 64 patients with PBC and 154 healthy controls. Results The genotype of all the 154 healthy subjects was GG, whereas the genotypes were GC in 2 patients and GG in 62 patients.There was statistically significant difference between the genotypes of the patients with PBC and healthy subjects(χ 2=4.86,P=0.028). Conclusions There is a probable genetic linkage between the G/C polymorphism of IL-6 gene at site-174 and the PBC.Increase in frequency of C gene may enhance the susceptibility of PBC.
出处
《武警医学》
CAS
2004年第7期518-520,共3页
Medical Journal of the Chinese People's Armed Police Force
