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紫杉醇对人腺样囊性癌细胞株ACC-2体外辐射增敏作用 被引量：1

Radiosensitizing Enhancement Effect of Paclitaxel on Human Adenoid Cystic Carcinoma ACC-2 Line Cell in vitro
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摘要 目的　评价紫杉醇对人腺样囊性癌细胞株 ACC- 2的辐射增敏作用。　方法　用克隆形成法检测不同时间 -浓度条件紫杉醇和 /或放射作用后的人腺样囊性癌细胞株 ACC- 2细胞存活分数 ,计算辐射增敏率 (SER)。　结果　紫杉醇对 ACC- 2细胞具有体外增殖抑制作用。人腺样囊性癌细胞株 ACC- 2的平均效应剂量 (D0 ) =1 .4 3Gy,Dq=3.6 Gy,1 0 ,1 0 0 ,1 0 0 0 nmol紫杉醇作用 2 4 h后 SER分别为 1 .2 9,1 .6 6和 1 .2 3。　结论　人腺样囊性癌细胞株 ACC- 2具有一定的辐射抗性。紫杉醇对其体外增殖抑制作用表现为时间 -浓度依赖性效应。一定条件下紫杉醇对人腺样囊性癌细胞株 ACC- Objective To investigate the radiosensitizing enhancement effect of paclitaxel on human adenoid cystic carcinoma ACC 2 line cell. Methods ACC 2 was treated by paclitaxel and/or radiation at different time and with different concentration. The survival percent was observed and calculated by cell coloning formation, and then sensitizer enhancement ratios(SER) were evaluated. Results Paclitaxel inhibited ACC 2 proliferation in vitro. Pretreatment of cells with 10, 100, 1000 nmol paclitaxel for 24 h, the SER were 1 29, 1 66, 1 23 respectively. Conclusion Paclitaxel has radiosensitizing enhancement effect on human adenoid cystic carcinoma ACC 2 line cell in vitro.
作者 施斌 林李嵩 陈乃俊 张纬建 林耿冰 朱小峰
机构地区 福建医科大学附属第一医院口腔颌面外科 福建医科大学附属第一医院放疗科
出处 《福建医科大学学报》 2004年第3期275-278,共4页 Journal of Fujian Medical University
基金 福建省教育厅科研基金资助项目 ( K0 2 0 73 )
关键词 癌 腺样囊性 紫杉酚 辐射增敏药 肿瘤细胞 培养的 carcinoma,adenoid cystic paclitaxel radiation sensitizing agents tumor cells, cultural
分类号 R739.8 [医药卫生—肿瘤]
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参考文献13

  • 1Kim KH,Sung MW.Adenoid cystic carcinoma of the head and neck[J].Arch Otolaryngol Head Neck Surg,1994,120:721-726.
  • 2Tishler RB,Schiff PB,Geard CR,et al.Taxol:a novel radiation sensitizer[J].Int J Radiat Oncol Biol Phys,1992,22(3):613-617.
  • 3鄂征.组织培养和分子细胞学技术[M](第2版)[M].北京:北京出版社,1997.129-131.
  • 4Rao S,Krauss NE.3'-(p-Azidobenzo-mido) taxol photolabels the N-terminal 31 amino acids of β-tubulin[J].J Biol Chem,1994,269(5):3132.
  • 5Spencer CM,Faulds D.Paclitaxel:a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer[J].Drugs,1994,48(2):794-847.
  • 6Sunwoo JB,Herscher LL,Kroog GS,et al.Concurrent paclitaxel and radiation in the treatment of locally advanced head and neck cancer[J].J Clin Oncol,2001,19(3):800-811.
  • 7Rosenthal DI,Lee JH,Sinard L,et al.Phase I study of paclitaxel given by seven-week continuous infusion concurrent with radiation therapy for locally advanced squamous cell carcinoma of the head and neck[J].J Clin Oncol,2001,19(5):1363-1373.
  • 8Sinclair WK.Cyclic X-ray responses in mammalian cells in vitro[J].Radiat Res,1968,33:620-643.
  • 9Tishler RB,Geard CR,Hall EJ,et al.Taxol sensitizes human astrocytoma cells to radiation[J].Cancer Res,1992,52:3495-3497.
  • 10Choy H,Rodriguez FF,Koester S,et al.Investigation of taxol as a potential radiation sensitizer[J].Cancer,1993,71:3774-3778.

共引文献7

同被引文献9

  • 1司徒镇强 吴军正.细胞培养[M].西安：世界图书出版公司,2001.186-187.
  • 2SUPIOT S, GOUARD S, CHARRIER J, et al. Mechanisms of cell sensitization to alpha radioimmunotherapy by doxorubicin or paclitaxel in multiple myeloma cell lines [J]. Clin Cancer Res, 2005, 11(19 Pt 2):7047s-7052s.
  • 3KIM J S, AMORINO G P, PYO H, et al. The novel taxane analogs, BMS-184476 and BMS-188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells[J]. Int J Radiat Oncol Biol Phys, 2001, 51 (2) : 525-534.
  • 4BACHE M, OEHLMANN S, MEYE A, et al. Radiosensitization in sarcoma cell lines with a p53 missense mutation correlates with prevention of irradiation G2/M arrest but not with induction of apoptosis[J]. Oncol Rep, 2001, 8(5);1007- 1011.
  • 5MASUNAGA S I, ONO K, SUZUKI M, et al. Radiosensitization effect by combination with paclltaxel in vivo, including the effect on intratumor quiescent cells[J]. Int J Radiat Oncol Biol Phys, 2001, 50(4):1063-1072.
  • 6MILAS L, MILAS M M, MASON K A, et al. Combination of taxanes with radiation: preclinical studies[J]. Semin Radiat Oncol, 1999, 9 (2 Suppl 1):12-26.
  • 7RAITANEN M, RANTANEN V, KULMALA J, et al. Paclitaxel combined with fractionated radiation in vitro : a study with vulvar squamous cell carcinoma cell lines [J]. Int J Cancer, 2002,97(6):853-857.
  • 8ATAAWIA M A, BORDEN M D, HERBERT K M, et al. Regional drug delivery with radiation for the treatment of Ewing's sarcoma, In vitro development of a taxol release system[J]. J Control Releasr, 2001, 71(2):193-202.
  • 9WOODS C M, ZHU J, MCQUENEY P A, et al. Taxol-induced mitotic block triggers rapid onset of a P-53 dependent apoptotic pathway[J]. Mol Med, 1995,1(5) :506-526.

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福建医科大学学报
2004年 第3期

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