摘要
目的 探讨急性胰腺炎 (AP)并发的胰性脑病 (PE)和韦尼克脑病 (WE)的临床特征和治疗方法。方法 回顾性分析了 10年来收治的AP患者 5 96例。结果 AP中重症急性胰腺炎 (SAP) 93例 ,脑病 10例(1 7% ) ,其中PE 6例 ,WE 4例 ;6例PE均为SAP ,占AP的 1%、SAP的 6 5 % ,其中死亡 3例 ,占SAP的 3%、PE的 5 0 %。 4例WE ,占AP的 0 7% ,死亡 2例 ,占AP的 0 3%、WE的 5 0 %。 2例WE注射维生素B1而治愈。结论 PE多发生在SAP的早期或病情反复时 ;WE发生于SAP或AP的恢复期。禁食时间长、反复呕吐及全胃肠外营养中未补充维生素B1是在胰腺炎病程中造成维生素B1缺乏而导致WE的重要原因。
Objective To investigate the clinical characteristics and the treatment of pancreatic encephalopathy (PE) and Wernicke's encephalopathy (WE). Method A retrospective study was conducted on 596 cases of acute pancreatitis. Results There were 93 cases of severe acute pancreatitis (SAP),among them encephalopathy was discovered in 10 patients (1.7%). All 6 patients of PE developed in SAP (6.5%);3 patients died (3% of SAP,50% of PE). Four cases of WE developed in AP (0.7%);2 patients died (0.3% of AP,50% of WE). Two patients of WE were treated with parenteral thiamine (vitamin B_ 1 ),and they survived. Conclusions PE occurred in early stage of SAP or recrudescence,while WE usually occurred in convalescent stage of SAP/AP. Long fasting,repeated vomiting,and total parenteral nutrition (TPN) without VitB_ 1 were main causes of VitB_ 1 deficiency,which might be the main causative factor in WE.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2004年第8期735-736,共2页
Medical Journal of Chinese People's Liberation Army
关键词
胰腺炎
急性
胰性脑病
韦尼克脑病
硫胺素
Acute pancreatitis
Pancreatic encephalopathy
Wernicke's encephalopathy
thiamine
