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2型糖尿病与β_3肾上腺素能受体基因Trp64Arg多态性的相关性探讨 被引量：1

Study on Codon 64 in the β_3-adrenergic Receptor Gene Mutation in Patients with Type 2 Diabetes Mellitus
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摘要 目的:探讨β_3肾上腺素能受体基因Trp64Arg突变在2型糖尿病发病中的意义。方法:PCR扩增52例2型糖尿病患者及123例对照者的β_3肾上腺素能受体基因Trp64Arg突变点,经限制性内切酶消化后行凝胶电泳确定其基因型。结果:β_3肾上腺素能受体基因Trp64Arg各种基因型频率在患者组与正常对照组之间的差异无显著性。结论β_3肾上腺素能受体基因Trp64Arg突变可能不是2型糖尿病的主要决定因素。 Objective:To explore the significance of gene mutations of codon 64 in the β_3-adrenergic receptor in patients with type 2 diab etes mellitus, and analyse the relation between them. Method: the genotyres of β_3-AR were determined by PCR-based assay in 52 patients with type 2 diabetes mellitus and 123 healthy controls. Results: there were no siganificant differences in the frequencies of β_3-AR mutations between the patients and control groups. Conclusion: β_3-AR may not be an independent risk factor for type 2 diabetes mellitus in Guangdong Chinese.
作者 李耀明 梁剑宁
机构地区 广东新会市人民医院
出处 《广州医学院学报》 2004年第2期60-62,共3页 Academic Journal of Guangzhou Medical College
关键词 2型糖尿病 β3肾上腺素能受体基因Trp64Arg 多态性 β_3-adrenergic receptor type 2 diabetes mellitus polymorphism
分类号 R587.1 [医药卫生—内分泌]
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参考文献11

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共引文献33

同被引文献20

  • 1惠宗光,周学伟,王晓玲,曹卫华,陈丽.2型糖尿病人群胰岛素抵抗和β_3-AR基因的相关性[J].潍坊医学院学报,2005,27(3):173-175. 被引量：3
  • 2李利,孙黎明,王军,董砚虎,司元国.β3肾上腺素能受体基因Trp^(64) Arg突变与胰岛素抵抗相关[J].中国医师杂志,2006,8(5):636-638. 被引量：1
  • 3姜秀云,侯新国,侯为开,任建民,陈丽.肾上腺素能β_3受体基因多态性与肥胖和胰岛素抵抗的相关性[J].中国糖尿病杂志,2007,15(9):526-527. 被引量：2
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引证文献1

广州医学院学报
2004年 第2期

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