摘要
目的:分析β-内酰胺类抗生素不良反应的特点,促进合理用药。方法:对重庆市ADR监测中心收到的β-内酰胺类抗菌药物ADR病例报告进行分析。结果:133例β-内酰胺类抗生素ADR病例报告中涉及26种β-内酰胺类抗菌药物,主要为头孢曲松钠(37例),青霉素(20例)和头孢噻肟钠(12例)。A型不良反应18例,B型不良反应115例,不良反应以过敏反应居多(98例)。反应程度绝大多数为轻、中度反应,重度反应15例,其中死亡1例。结论:应合理使用β-内酰胺类抗生素,避免和减少不良反应的发生。
Objective: To analyse the characterization of adverse reactions to beta-lactam antibiotics for rational drug use. Methods: 133 case reports of ADR associated with beta-lactam antibiotics were collected and analysed by Chongqing ADR Monitoring Center. Results: 26 drugs were involved in 133 ADR case reports, including ceftriaxone sodium (37 cases,constituting 27.82% of all cases), benzylpenicillin(20 cases,15.04%)and cefotaxime sodium(12 cases, 9.02%). There were 18 cases of type A reaction and 115 cases of type B reaction, among them allergic reactions in 98 cases(73.68%). Serious reactions amounted to 15 cases, of which 1 case died. Conclusion: Rational use of beta-lactam antibiotics should be emphasized in the clinical practice in order to prevent and reduce the occurrence of ADRs.
出处
《药物不良反应杂志》
2004年第4期235-239,共5页
Adverse Drug Reactions Journal
