摘要
目的 :探讨非小细胞肺癌组织中微血管密度 (microvesseldensity ,MVD)与肺癌临床病理特征的关系。方法 :采用S P免疫组化法 ,检测 5 7例肺癌组织MVD ,研究微血管表达与非小细胞肺癌病理分型、临床分期及淋巴结转移的关系。结果 :MVD与肺癌淋巴结转移状态、分期、细胞分化程度等均有密切关系 (P <0 .0 1 ) ,而与肺癌患者性别、组织学类型、原发肿瘤大小等均无明显关系 (P >0 .0 5 )。结论 :MVD在肺癌的发生、发展、转移中起重要作用 。
Objective:To study the relationship between microvessel density(MVD) of non small cell lung cancer(NSCLC) tissues and the clinicopathological characteristics.Methods:The MVD was detected in 57 NSCLC tissues by immunohistochemical staining(S P method) and the relationship of MVD to the clinical staging,pathologic typing and lymph node metastasis was studied.Results:MVD was closely related to the lymph node status,clinical staging and grade of cell differentiation of NSCLC( P <0.01),but not to the size of primary cancer,the histological classification and sex( P >0.05).Conclusions:MVD may play an important role in the oncogenesis,development and metastasis of NSCLC and is one of the reliable prognostic indicator of survials of NSCLC.
出处
《蚌埠医学院学报》
CAS
2004年第5期383-384,共2页
Journal of Bengbu Medical College
基金
安徽省教育厅自然科学研究资助项目 ( 2 0 0 0JL166)
关键词
癌
非小细胞肺
微血管密度
免疫组织化学
carcinoma,non small cell lung
microvessel density
immunohistochemistry
