摘要
目的 调查发现在所研究的 2型糖尿病病例中 ,体内胰岛素抵抗与胰岛素缺乏的程度。方法 1990～ 1994年间门诊及住院的 2型糖尿病 2 46例 ,均未使用胰岛素治疗。按照病程分为 4组。所有的患者均在空腹取静脉血测定血糖及胰岛素水平。计算HOMA模型胰岛素抵抗指数和 β细胞功能指数。 结果 各组病例均没有明显的高胰岛素血症 ,其胰岛素抵抗指数无明显差异 ;糖尿病病程与空腹胰岛素水平及 β细胞功能指数呈负相关性 ,与空腹血糖水平呈正相关性。结论 在所研究的
Objective To investigate the degree of insulin resistance and insulin secretary defect in the different courses of the researched Chinese type 2 diabetes mellitus.Methods Outpatient or inpatient cases were chosen from 1990 to 1994 at Peking Union Medical College Hospital,none of them were treated with insulin.They were divided into 4 groups according to the duration of diabetes mellitus.We measured all the subjects fasting blood glucose and insulin level.HOMA-IR and HOMA-β were estimated by homeostasis model assessment.Results No Hyperinsulinemia was found in the researched Chinese type 2 diabetes.There was no difference of HOMA-IR among the groups.The duration of disease is positively related with fast blood glucose,but negatively related with fasting insulin level and HOMA-β.Conclusion From the result of research,we can see that insulin secretary defect was more common than hyperinsulinemia in type 2 DM. [
出处
《临床内科杂志》
CAS
北大核心
2004年第9期594-596,共3页
Journal of Clinical Internal Medicine
关键词
糖尿病
胰岛素抵抗
胰岛素缺乏
Diabetes mellitus
Insulin resistance
Insulin deficiency
