摘要
目的 :对微弧氧化 (microarcoxidation ,MAO)处理的纯钛材料进行动物皮下埋置实验 ,以评价MAO处理的纯钛材料的生物相容性及材料 -软组织反应。方法 :选取纯钛材料经过MAO处理后 ,在无菌手术条件下植入家兔的背部浅筋膜下 ,以相同规格的纯钛试件作为对照 ,采用GB/T16 886 .6的国家医疗器械生物学评价标准 ,对此种材料的生物相容性进行评价 ,对取出的标本进行扫描电镜的观察及能谱分析。结果 :所有实验动物在实验过程中未发现异常现象 ,组织学观察发现MAO组与对照组试件周围形成的纤维囊壁均匀 ,厚度一致 ,未发现异常的炎症细胞聚集和浸润 ,未见到MAO组试件涂层脱落现象。将MAO组试件取出后进行SEM观察 ,见其材料表面沉积有少量的磷酸钙盐颗粒 ,并含有较高比例的N ,C元素 ,对照组试件未见到磷酸钙盐颗粒 ,N ,C元素的含量较低。结论 :进行动物皮下埋置的MAO处理后纯钛材料没有明显局部炎症反应 。
Objective: To assess the biocompatibility and material-tissue interaction of pure titanium after micro-arc oxidation (MAO) treatment by subcutaneous implantation experiment. Methods: According to National Standard of Medical Appliance (GB/T16886.6), rabbits were chosen to assess the biocompatibility of MAO titanium surface. MAO titanium material was implanted on the back of rabbits subcutaneously with control of pre titanium. Tissue biocompatibility was evaluated by HE tissue sections, and material after implantation was observed by SEM and EDX. Results: No abnormal animal reaction was found during surgical experiments. No abnormal inflammation cells infiltration was found around MAO implants, with thin uniform fibroblast cyst same as implants of control group. Calcium phosphate, carbon and nitrogen element were found on the MAO implant surface, while less quantity of carbon and nitrogen element were found on implants as control. Conclusion: MAO titanium showed good biocompatibility and calcium phosphate inducement ability with no prominent local inflammation reaction in animal experiments.
出处
《口腔医学研究》
CAS
CSCD
2004年第4期376-378,共3页
Journal of Oral Science Research
关键词
钛
微弧氧化
生物相容性
皮下埋置实验
Titanium Microarc oxidation Biocompatibility Subcutaneous implantation
