摘要
目的 观察舒脉胶囊对冠心病心绞痛的疗效及对血小板α颗粒膜蛋白 (GMP 14 0 )和蛋白C(PC)的影响。方法 85例冠心病心绞痛患者随机分为治疗组 (5 2例 ,常规西药加舒脉胶囊治疗 )和对照组 (33例 ,常规西药治疗 )。结果 治疗组中医证候总有效率 94 .2 3% ,心绞痛总有效率 94 .2 3% ,心电图总有效率 6 1.5 4 % ,均优于对照组 (分别为 81.82 % ,78.79 % ,4 5 .4 5 % ,P均 <0 .0 5 )。治疗后血浆GMP - 14 0含量由 (2 3.0 5± 5 .2 8)ng/mL降至 (11.2 0± 2 .6 4 )ng/mL ,PC活性由(5 2 .0 5± 4 .4 8) %升至 (6 6 .79± 7.12 ) % ,治疗前后GMP - 14 0和PC差值与对照组比较有显著性差异 (P <0 .0 5 )。结论 舒脉胶囊加常规西药治疗冠心病心绞痛的疗效明显优于单纯常规西药治疗。
OBJECTIVE To observe the effect of Shumai Capsule on the patients suffering from coronary heart disease with angina pectoris. METHOD 85 patients were divided randomly into a treatment group (52 patients, treated with routine western medicines and Shumai Capsule) and a control group (33 patients, treated with only routine western medicines) RESULT In the treatment group, the total effective rate, angina pectoris total effective rate and ECG total effective rate were 94.23%, 94.23% and 61.54% respectively, which were higher than those in the control group (81.82%, 78.79% and 45.45%,P<0.05). After the treatment, the content of plasma GMP-140 dropped from 23.05±5.28 ng/mL to 11.20±2.64 ng/mL, and PC activity rose from 52.05±4.48% to 66.79±7.12%. The two values changed significantly as compared with those before the treatment (P<0.05). CONCLUSION Shumai Capsule combined with western medicines is more effective than simple western medicines in the treatment of coronary heart disease with angina pectoris.
出处
《南京中医药大学学报》
CAS
CSCD
2004年第5期292-294,共3页
Journal of Nanjing University of Traditional Chinese Medicine
基金
山东省科技厅基金项目 ( 9910 2 5 0 70 6)
关键词
舒脉胶囊
心绞痛
血小板α颗粒膜糖蛋白
蛋白C
Shumai Capsule
angina pectoris
platelet α granulosa glucoprotein
protein C
