摘要
目的 通过对转抗菌肽CAD基因酵母饲料添加剂的安全性评价 ,研究和建立转基因饲料安全性的评价模型和检验方法。方法 通过对受体生物和外源基因表达产物的安全性 ,转基因酵母生物性状的遗传稳定性 ,抗菌杂合多肽基因及产物在环境和饲养动物体内的转移和蓄积等进行检验和评价 ,确认产品的安全性。结果及结论 转抗菌肽CAD基因酵母饲料的受体生物、外源基因表达产物是安全的 ,产品具有稳定的遗传性状 ,抗菌杂合肽CAD在饲养动物体内不蓄积 ,抗菌肽CAD基因不向其他微生物转移 。
Objective To evaluate the safety of GM yeast feed additive with cecropin CAD and to study and set up a model of Safety assessment for GM feed and detecting method. Methods To ensure the safety of the GM products, it has been done that to detect and value the safety of receiptor organisms and expression products of extrinic gene, the genetic stability of biologic properties of genomic modified yeast feed and condition of transfer and cumulation of anti-bacterial peptide and its products in circumstance and the feeded animals. Result and conclusion The receiptor animals and expression products of extrinic gene are safe, and the genomic modified products have steady genetic characters. The cecropin CAD neither cumulates in feeded animal nor releases into environoment. The genomic modified feed additive is safe.
出处
《卫生研究》
CAS
CSCD
北大核心
2004年第5期565-569,共5页
Journal of Hygiene Research
基金
2 0 0 1年广东省科研基金项目 (No .C31 4 0 3)
