期刊文献+

霉酚酸酯治疗慢性移植物功能减退的多中心研究

Treatment of chronic allograft dysfunction with mycophenolate mofetil after kidney transplantation:a multicenter study
原文传递
导出
摘要 目的 探讨霉酚酸酯 (MMF)治疗慢性移植物功能减退 (CAD)的疗效和安全性。方法 应用霉酚酸酯 (MMF)替换硫唑嘌呤 (Aza)或环磷酰胺 (CTX) ,并联合小剂量环孢素A(CsA)和泼尼松 (Pred )治疗 78例CAD患者的方案。平均随访 9.84个月 ,研究并分析该方案的效果和并发症。结果 应用MMF联合小剂量CsA和Pred治疗后 ,有 74例患者的血清肌酐 (SCr)下降 ,随访时与应用前比较 ,差异有显著性 (P <0 .0 5 ) ;治疗有效率达 94 .9% ;4例治疗无效。用MMF转换治疗后 ,尿蛋白减轻或消失 ,血压下降。贫血、腹泻等不良反应发生率为 33.3%。结论 MMF联合小剂量CsA和Pred治疗CAD是有效和安全的。贫血、腹泻是转换治疗的主要副作用。 Objective To investigate the therapeutic effectiveness and safety of mycophenolate mofetil (MMF) in the treatment of chronic allograft dysfunction (CAD).Methods Seventy-eight patients with CAD were administrated with MMF substituting for Aza or CTX with concomitant low-dose CsA. The effectiveness and complications were analyzed. The mean follow-up time after MMF treatment was 9.48 months.Results After treatment with MMF in combination with low doses of CsA and Pred,the serum creatinine concentration (SCr) in 74 CAD patients was significantly decreased and remained stable at the end of follow-up ( P < 0.05 ). Four out of 78 CAD patients finally failed. The total effective rate was 94.9 % . Blood pressure was lowed and proteinuria attenuated or abolished after MMF treatment. The rate of adverse effects was 33.3 % .Conclusions MMF combined with low-dose CsA and Pred is an effective and safe regime for the treatment of CAD. Side effects of MMF regime as diarrhea and anaemia were observed.
作者 薛武军 燕航
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2004年第4期237-239,共3页 Chinese Journal of Organ Transplantation
基金 上海罗氏制药有限公司资助
关键词 霉酚酸酯 慢性移植物功能减退 MMF CAD 肾移植 不良反应 Renal transplantation Mycophenolate mofetil Chronic allograft dysfunction
  • 相关文献

参考文献12

  • 1Ducloux D, Motte G, Billerey C, et al. Cyclosporin withdrawal with concomitant conversion from azathioprine to mycophenolate mofetil in renal transplant recipients with chronic allograft nephropathy: a 2-year follow-up. Transpl Int, 2002,15: 387-392.
  • 2Azuma H. Chronic allograft nephropathy: its diagnosis and treatment. Hinyokika Kiyo, 2002,48:679-682.
  • 3Morozumi K, Takeda A, Uchida K. Pathogenesis of chronic renal allograft dysfunction. Hinyokika Kiyo, 2002,48: 673-677.
  • 4Metcalfe MS, Jain S, Waller JR, et al. A randomized trial of mycophenolate mofetil versus azathioprine as calcineurin inhibitor sparing agents in the treatment of chronic allograft nephropathy. Transplant Proc,2002, 34:1812-1814.
  • 5Pilmore HL, Dittmer ID. Calcineurin inhibitor nephrotoxicity: reduction in dose results in marked improvement in renal function in patients with coexisting chronic allograft nephropathy. Clin Transplant, 2002,16:191-195.
  • 6Pilmore HL, Dittmer ID. Calcineurin inhibitor nephrotoxicity: reduction in dose results in marked improvement in renal function in patients with coexisting chronic allograft nephropathy. Clin Transplant, 2002,16:191-195.
  • 7Khachatryan N, Wauters JP, Vogel G. Effect of mycophenolate mofetil in combination with standard immunosuppression on chronic transplant nephropathy: 1 year experience. Transplant Proc, 2002,34 : 807-808.
  • 8Rush DN, Nickson P, Gough J, et al. Beneficial effects of treatment of early subclinical rejection: a randomized study. J Amer Soc Nephrol, 1998, 9:2129-2134.
  • 9Gonzalez Molina M, Seron D, Garcia del Moral R, et al. Treatment of chronic allograft nephropathy with mycophenolate mofetil after kidney transplantation: a spanish multicenter study. Transplant Proc, 2002; 34: 335-337.
  • 10章咏裳.浅谈改善肾移植疗效的几个问题[J].中华器官移植杂志,2000,21(1):5-5. 被引量:11

二级参考文献25

  • 1Ishikawa H. Mizoribine and mycophenolate mofeil[J]. Curr Med Chem,1999,6(7):575-597.
  • 2Sollinger HW. Update of preclinical and clinical experience with mycophenolate mofetil[J]. Transplant Proc, 1996, 28(6 Suppl 1):24-29.
  • 3Groth CG. The European experience with mycophenolate mofetil[J]. Transplant Proc, 1996, 28(6, suppl):30-33.
  • 4Tomlanovich SJ. Rescue therapy with mycophenolate mofetil [J]. Transplant Prod, 1996, 28(6, Suppl):34-36.
  • 5Morris SG, Jurewicz WA. Single centre experience with mycophenolate mofetil for refractory rejection in cadaveric renal transplantation[J]. Transpl Int, 1998,11(3):204-207.
  • 6Zanker B, Schneeberger H, Rothenpieler U, et al. Myeophenolate mofetil- based, cyclosporine- free induction and maintenance immunosuppression: first-3-months analysis of efficacy and safety in two cohorts of renal allograft recipients[J].Transplantation, 1998, 66(1):44-49.
  • 7Hebert MF, Aschet NL, Ascher NL, et al. Four years follow-up of mycophenolate mofetil for graft rescue in liver allograft recipients[J]. Transplantation, 1999,67(5):707-712.
  • 8Mathieu P, Carrier M, White M, et al. Effect of mycophenolate mofetil in heart transplantation[J]. Can J Surg, 2000,43(3):202-206.
  • 9Langman LJ, LeGatt DF, Halloran PF, et al. Pharmacodynamic assessment of mycophenolic acid-induced immunosuppression in renal transplant recipients[J]. Transplantation, 1996,62(5):666-672.
  • 10Dore Duffy P, Newman W, Balabanov R, et al. Circulation, soluble adhesion proteins in cerebrospinal fluid and serum of patients with multiple sclerosis: correlation with clinical activity[J]. Ann Neurol, 1995,37(1):55 -62.

共引文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部