摘要
目的 探讨宫颈癌组织中caspase 3与nm2 3 H1基因表达的特征及相关性。方法 应用免疫组织化学方法 (SP法 )分别检测caspase 3和nm2 3 H1基因在 4 1例宫颈癌组织、17例宫颈上皮内瘤样病变 (CIN)和 10例正常宫颈组织中的表达 ,分析其与临床病理特征的相关性。结果 caspase 3在宫颈癌组织和CIN中的阳性表达率均明显低于正常宫颈组织中的阳性表达率 (P <0 0 5 ) ;caspase 3的表达与宫颈癌的组织类型、病理分级和临床分期无相关性 (P >0 .0 5 )。nm2 3 H1基因在宫颈癌组织中的阳性表达率与CIN及正常宫颈组织相比均具有显著性差异 (P <0 0 5 ) ;nm2 3 H1的阳性表达与宫颈癌的临床分期、组织类型、病理分级无相关性 (P >0 0 5 )。caspase 3基因的表达与nm2 3 H1基因的表达无相关性 (P >0 0 5 )。结论 caspase 3和 /或nm2 3 H1基因的表达降低与宫颈癌的发生密切相关。
Objective This study was to investigate the correlation between the expression of caspase-3 and nm23-H 1 and the clinical value in cervical cancer.Methods Immunohistochemical S-P methods were used to examine the expression of caspase-3 and nm23-H 1 genes in 41 cervical cancer tissues and 17 CIN cervical tissues and 10 normal cervical tissues.The relationship between the expression and clinical pathology was analyzed.Results The positive rate of caspase-3 gene in cervical cancer and CIN was significantly lower than that in normal cervical tissues(P<0.05).The expression of caspase-3 has no correlation with the tissue type、 pathology grade and clinical stage P>0.05 .The positive rate of nm23-H 1 gene in cervical cancer significantly lower than that in CIN and normal cervical tissues(P<0.05).There was no relationship between nm23-H 1 expression and the tissuetype、 pathology grade and clinical stage (P>0.05).Conclusion The positive rate of caspase-3 and/or nm23-H 1 gene is closely related to the onset of cervical cancer.
出处
《医药论坛杂志》
2004年第11期41-43,45,共4页
Journal of Medical Forum
