摘要
目的探讨乙型肝炎病毒相关性肾炎经α-干扰素治疗的临床病理变化。方法32例HBV相关性肾炎给予α-干扰素100～300万U,肌肉注射,6个月为一疗程,比较治疗前后血清白蛋白浓度,24h尿蛋白定量及肾组织乙肝抗原、HBV-DNA、IgG、IgM、IgA阳性率。结果α-干扰素治疗后血清白蛋白浓度升高、尿蛋白定量下降;肾组织乙肝抗原、HBV-DNA、IgA、IgM、IgG阳性率均显著下降(P<0.01)。结论乙型肝炎病毒相关性肾炎经α-干扰素治疗后临床病理有较显著改善。
Objective To study the clinical pathologic changes of hepatitis B virus associated glomerulonephritis follow alpha interferon.Methods Thirty two patients with hepatitis B virus associated glomerulonephritis received alpha interferon.Later six months after the therapy the difference between pre-and post-treatment in albumin,24h-urinary protein,and the positive rates of HBAg,HBV-DNA,IgG,IgM,IgA in the renal tissue were compared.Result After the alpha interferon therapy,the albumin increased,and the24h-urinary protein decreased,all the positive rates above also decreased significantly.Conclusion Alpha interferon is effective in HBV associated glomerulonephritis either in cliniclc or in pathology.
出处
《实用医药杂志》
2004年第7期587-588,共2页
Practical Journal of Medicine & Pharmacy
