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α-干扰素治疗慢性乙型肝炎5年随访 被引量:3

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摘要 目的 观察α 2b干扰素治疗慢性乙型肝炎的远期疗效 ( 5年 )。方法 慢性乙型肝炎 13 2例 ,随机分为两组 ,治疗组应用α 2b干扰素 3Mu~ 5Mu ,肌注 ,隔日 1次 ,疗程 6月 ;对照组应用一般保肝降酶药 ,疗程 6月。结果 治疗组与对照组疗程结束后总有效率分别为 5 1.5 %、8.5 7%,差别非常显著。随访 5年 ,治疗组的长期应答率 ( 4 5 .1%~ 61.2 %)远较对照组 ( 8.5 7%~ 2 1.4%)高 ,差别非常显著。结论 重组α 2b干扰素具有较好的抗病毒作用 ,通过长期清除或抑制乙型肝炎病毒 ,减少复发 ,从而减轻肝脏炎症及纤维化程度 。
作者 袁念芳 陈文
出处 《实用肝脏病杂志》 CAS 2004年第3期163-164,共2页 Journal of Practical Hepatology
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