摘要
目的 分析原发闭经患者染色体核型与病因。方法 分析 6 1例原发闭经患者外周血淋巴细胞染色体核型。结果 6 1例原发闭经患者检出 2 0例异常核型 ,占受检者 32 79% ,其中性染色体异常 18例 ,占异常核型 90 0 0 % ;常染色体异常 2例 ,占异常核型 10 0 0 %。 4 1例染色体正常 ,其中单纯性腺发育不全 2 7例 ;先天无子宫、无阴道 10例 ;4例患者出现男性化特征。结论 染色体异常是导致原发闭经的重要原因之一。
Objective: To analyze abnormal chromosome karyotype and pathogenesis of primary amenia. Methods: To analyze the chromosome karyotypes of circular lymphocytes in 61 patients with primary amenia. Results: of 61case,20 cases with primary amenia were abnormal karyotype(32.79%). 18 cases of them were abnormal sex chromosome, with take up about 90% in abnormal karyotype; 2 cases of them were abnormal autosomal chromosome, with take up about 10% in abnormal kayotype. 41 cases with primary amenia were normal karyotype,27 of them were pure sexual dysgenesis; 10 of them were congenital absence of uterus and vagina; 4 patients have male tendency character. Conclusion: Abnormal chromosome plays an important role in pathogenesie of primary amenia.
出处
《中国优生与遗传杂志》
2004年第4期71-72,共2页
Chinese Journal of Birth Health & Heredity
关键词
原发闭经
异常棱型
分析
Primary amenia
Abnormal karyotype
Analysis
