摘要
背景:肿瘤坏死因子α(tumornecrosisfactor-α,TNF-α)和胰岛素抵抗(insulinresistance,IR)都是脑血管病的危险因素,拮抗TNF-α能否改善IR及减轻脑血管病患者脑损伤?目的:探讨急性脑梗死患者TNF-α和IR的改变及其相互关系。设计:以诊断为依据的病例对照研究。地点和对象:广西壮族自治区百色市人民医院2000-01/2003-02符合全国第二次脑血管病会议诊断标准的48例急性脑梗死患者(急性脑梗死组)和36例健康体检者(正常对照组)。干预:所有入选对象均于清晨空腹抽取静脉血测定血糖(fastingplasmaglucose,FPG),血清胰岛素(fastinginsulin,FINS),TNF-α。血糖测定方法采用氧化酶法,血清胰岛素测定用放射免疫法,TNF-α采用酶标法。主要观察指标:急性脑梗死组和正常对照组的FPG,FINS,TNF-α的水平。结果:急性脑梗死组的TNF-α水平为(205±78)ng/L,FINS为(6.18±1.72)mmol/L,FPG为(12.74±4.33)mU/L,均高于对照组犤(76±18)ng/L,(5.25±1.28)mmol/L,(7.18±2.58)mU/L犦,其中急性脑梗死组的TNF-α水平和FINS与对照组比较,差异有显著性意义(t=9.72,7.33,P<0.01);血清TNF-α与FINS呈正相关(r=0.53,P<0.01)。结论:急性脑梗死患者可有IR和TNF-α水平增高,TNF-α与IR有密切相关性,两者可能共同参与缺血性脑血管病的发生和?
BACKGROUND:Since both tumor necrosis factor-alpha(TNF-α)and insulin resistance(IR) are the risk factors cerebrovascular diseases,is it possible to alleviate IR and reduce cerebral injury in patients with acute cerebral infarction when TNF-αis antagonized?OBJECTIVE:To explore changes of TNF-αand IR and their correlation in acute cerebral infarction patients.DESIGN:Case-controlled research based on diagnosis.SETTINGS and PARTICIPANTS:Thirty-six healthy people and 48 acute cerebral infarction patients in Baise Municipal People's Hospital,Guangxi Zhuang Autonomous Region,who were accepted from January 2000 to February 2003 and in accord with the diagnosis criterion of the Second National Cerebral Vascular Diseases Conference.INTERVENTIONS:Fasting plasma glucose(FPG),fasting insulin(FINS) and TNF-αin every objective were measured by fasting venous blood collection in morning.Oxidase test,radioimmunoassay and the enzyme labeling were adopted respectively in the measurement of FPG,FINS and TNF-α.MAIN OUTCOME MEASURES:FPG,FINS and TNF-αin both acute cerebral infarction group and control group.RESULTS:In acute cerebral infarction group,TNF-αlevel was(205 ±78) ng/L,FINS(6.18±1.72) mmol/L,FPG(12.74±4.33) mU/L,all of them were higher than those in the control group[(76±18) ng/L,(5.25±1.28) mmol/L,(7.18±2.58) mU/L].Moreover, significant difference could be detected when TNF-αlevel and FINS in acute cerebral infarction group were compared with those in the control group(t=9.72,7.33,P< 0.01);TNF-αlevel was positively correlated with FINS(r=0.53,P< 0.01).CONCLUSION:Both IR and TNF-α,which increase in acute cerebral infarction patients and have a close correlation,may participate in the occurrence and development of ischemic cerebral vascular diseases;Therefore,it is possible to alleviate IR and reduce cerebral injury in patients with acute cerebral infarction when TNF-αis antagonized.
出处
《中国临床康复》
CSCD
2004年第25期5434-5435,共2页
Chinese Journal of Clinical Rehabilitation
