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IL-23研究进展 被引量：1

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摘要 IL 2 3是新近发现的一种促炎性细胞因子 ,隶属于IL 12分子家族。类似于IL 12 ,IL 2 3是由两种亚单位 (p4 0和p19)通过二硫键形成的异二聚体分子 ,二者的生物学功能也有很多相似之处 ,但并不完全相同 ,提示IL 2
作者 曹菲 李家文
机构地区 华中科技大学同济医学院（硕士研究生） 华中科技大学同济医学院
出处 《国外医学（免疫学分册）》 2004年第5期264-267,共4页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
基金 湖北省卫生厅科学基金 (JX1B0 48)
关键词 IL-23 IL-12 IL-12分子家族 促炎性细胞因子
分类号 R392.11 [医药卫生—免疫学]
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参考文献20

  • 1Becher B, Durell BG, Noelle RJ. IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis[J]. J Clin Invest, 2003,112 (8): 1186-1191.
  • 2Elkins KL, Cooper A, Colombini SM, et al. IN vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40subunit of interleukin-12 (IL-12) but not on IL-12 p70[J].J Infect Immun, 2002,70(4): 1936-1948.
  • 3Wiekowski MT, Leach MW, Evans EW, et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death[J]. J Immunol, 2001,166(12) :7563-7570.
  • 4Cooper AM, Kipnis A, Turner J, et al. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present[J] .J Immunol, 2002,168(3):1322-1327.
  • 5Belladonna ML, Renauld JC, Bianchi R et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells [J]. J Immunol,2002,168(11):5448-5454.
  • 6Aggarwal S, Chilardi N, Xie MH, et al. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17[J].J Biol Chem,2003,278(3) :1910-1914.
  • 7Lehmann J, Bellmann S, Wemer C, et al. IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis[J].J Immunol,2001,167(9) :5304-5315.
  • 8Pirhonen J, Matikainen S, Julkunen I. Regulation of virus-induced IL-12and IL-23 expression in human macrophages[J]. J Immunol, 2002,169(10): 567.3-5678.
  • 9Ha SJ, Kim DJ, Baek KH, et al. IL-23 induces stronger sustained CTL and Th1 immune response than IL-12 in hepatitis C virus envelope protein 2DNA immunization[J] .J Immunol,2004,172(1) :525-531.
  • 10Becher B, Durell BG, Noelle RJ. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12[J]. J Clin Invest,2002,110(4) :493-497.

同被引文献7

  • 1Roilides E, Tsaparidou S, Kadiltsolou I, et al. lnterleukin - 12 enhances antifungal activity of human mononuclear phagocytes against Aspergillus fumigatus. Infect Immunol 1999 ; 67 : 3047 - 3050.
  • 2Romani L, Puccetti P, Bistoni F. Interleukin- 12 in infectious diseases. Clin Microbiol Rev 1997; 10:611 - 636.
  • 3Cua DJ, Sherlock J, Chen Y, et al. Interleukin - 23 rather than interleukin - 12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003;421:744 - 748.
  • 4Elkins KL, Cooper A, Colombini SM, et al. IN vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin- 12 (IL- 12) but not on IL- 12 p70. J Infect Immunol 2002;70:1936 - 1948.
  • 5Wey SB, M Mori, MA Pfaller, et al. Hospital - acquired candidemia. The attributable mortality and excess length of stay. Arch Intern Med 1988; 148:2642 - 2645.
  • 6Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL- 12p40 to form a cytokine, IL- 23, with biological activities similar as well as distinct from IL- 12. Inmunity 2000; 13:715-725.
  • 7Montagnoli C, Bozza S, Bacci A, et al. A role for antibodies in the generation of memory antifungal immunity. Eur J Immunol 2003 ; 33 : 1193 - 1204.

引证文献1

二级引证文献2

国外医学（免疫学分册）
2004年 第5期

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