摘要
目的 探讨近年来南京市肺癌发生的环境危险因素。方法 对南京市 63例原发性肺鳞癌和 89例原发性肺腺癌进行 1∶1配对病例 -对照研究 ,并用条件Logistic回归模型分析危险因素。 结果 慢性支气管炎史、吸烟指数是肺鳞癌发生的环境危险因素 ,其OR值分别为 8 55,2 3 5;人群归因危险度分别为 18 2 2 % ,58 80 % ;综合人群归因危险度为 0 6871。慢性支气管炎史、肺结核史、不良烹调习惯、煤炉使用年限、家族肿瘤史是肺腺癌发生的环境危险因素 ,OR值分别为 5 16,4 12 ,2 91,2 0 2 ,2 59;人群归因危险度分别为 8 15% ,11 91% ,2 7 3 0 % ,2 9 98% ,10 3 5% ;综合人群归因危险度为 0 63 0 6。结论 肺鳞癌、腺癌的发病分别与多种环境因素有关 ,应积极控制环境危险因素 。
ObjectiveTo study the environmental!risk factors of lung cancer in Nanjing population. MethodsA 1∶1 match case-control study was carried out,w hich involved 63 cases of primary pulmonary squamous cell carcinoma and 89 cases of pulmonary adenocarcinoma.The environmental risk factors were analyzed by con ditional logistic regression model.ResultsChronic bronchitis and quantity of smoking were f ound to be risk factors to lung squamous cell carcinoma.The OR value was 8.5 5,2. 35,respectively,and population attributable risks (PAR) for each of them was 18. 22%,58.80%,respectively,the total PAR was 68.71%.The risk factors related to lun g adenocarcinoma were chronic bronchitis,the history of pulmonary tuberculosis,b ad cooking habituation,use of coal stove and family histoty of cancer.The respec tive OR value was 5.16,4.12,2.91,2.02,2.59,and PAR was 8.15%,11.91%,27.30%,2 9.98%,10.35%,respectively.Summary PAR for the five factors above was 63.06%.ConclusionThe development of pulmonary squamous cell car cinoma and adenocarcinoma was related with various environmental factors respect ively.Strengthening the control of the environmental risk factors was suggested to reduce the incidence of lung cancer.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2004年第3期260-261,共2页
Chinese Journal of Public Health
基金
国家自然科学基金 ( 30 1 70 791 )
江苏省社会发展基金(BS2 0 0 0 0 34 )
关键词
肺癌
环境危险因素
人群归因危险度
lung cancer
environmental risk factors
populat ion attributable risk(PAR)
