摘要
目的 研究黑米皮对载脂蛋白E(apoE)基因缺陷小鼠主动脉窦CD+ 4和CD+ 8T淋巴细胞表达的影响 ,探讨黑米皮抗动脉粥样硬化 (AS)作用的机制。方法 选用apoE基因缺陷小鼠进行实验 ,通过在apoE基因缺陷小鼠普通饲料AIN -93中添加 5%黑米皮 ,检测apoE基因缺陷小鼠主动脉窦动脉粥样斑块面积和CD+ 4、CD+ 8T淋巴细胞表达的水平。结果 黑米皮可降低apoE基因缺陷小鼠主动脉窦动脉粥样斑块面积以及CD+ 4T淋巴细胞表达的水平。结论 黑米皮的抗AS作用与其抑制CD+
ObjectiveTo explore the effect of black rice outer layer fraction (BRF) on CD\++\-4 T,CD\++\-8 T lymphocyte expression in apoE-deficien t mice and find the possible mechanism of BRF in anti-atherogenesis. MethodsCD\++\-4 T and CD\++\-8 T lymphocyte expression i n aortic sinus and atherosclerotic lesion area in aortic sinus were assessed by immunohistochemistry and image analysis,respectively. ResultsBRF inhibited CD\++\-4 T lymphocyte expression an d atherosclerotic lesion area in aortic sinus. ConclusionBRF dramatically reduced CD\++\-4 T lymphocyte expression and this effect maybe related to its anti-atherogenesis.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2004年第3期266-267,共2页
Chinese Journal of Public Health
基金
国家自然科学基金杰出青年基金资助( 30 0 2 50 37)
关键词
黑米皮
载脂蛋白E基因缺陷小鼠
T淋巴细胞
black rice outlayer fraction
apolipoprotein E- deficient mice
T lymphocyte
