摘要
目的 探讨低剂量电离辐射和低浓度丝裂霉素C之间的交叉适应性反应规律。方法 以人淋巴细胞、小鼠骨髓细胞为实验材料 ,分别用低剂量X射线或低浓度丝裂霉素C作适应性处理 ,再用高浓度丝裂霉素C或大剂量X射线作攻击性处理。观察人淋巴细胞染色体畸变、微核、SCE ,小鼠骨髓细胞染色体畸变。结果 人淋巴细胞染色体畸变、SCE ,小鼠骨髓细胞染色体畸变分别呈现出低剂量X射线与低浓度丝裂霉素C的交叉适应性反应。结论 无论在离体条件下 ,还是在哺乳动物体内 ,低剂量辐射与低浓度丝裂霉素C之间存在着相互的交叉适应性反应现象。
ObjectiveTo probe the laws of the cross-adapting respons e induced by low dose radiation and low concentration mitomycin C.MethodsThe human lymphocytes,bone marrow cells of mice w ere treated by low dose X-ray or low concentration mitomycin C before treated b y high dose X-ray or high concentration mitomycin C.Some targets were observed,s uch as chromosome aberration of human lymphocytes,bone marrow cells of mice,micr onuclear(MN),sister chromatied exchange(SCE).ResultsThe targets of above all appeared cross-adapt res ponse.ConclusionCross-adapt response can be inducd by low dose radiation or by low concentration mitomycin C not only in vivo but also i n vitro.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2004年第3期316-317,共2页
Chinese Journal of Public Health
关键词
低剂量电离辐射
低浓度丝裂霉素C
染色体畸变
交叉适应性反应
low dose ionizing radiation
low concentration mitomycin C
chromosome aberration
cross-adapt response
