摘要
目的 :通过研究新生儿脓毒症血清TNFα、IL - 10的浓度水平及IL - 10 /TNFα比值的变化 ,评价患儿的免疫状况及其与疾病的严重程度和预后的关系。方法 :在患儿被诊为脓毒症后的d1、d3、d5、d7、d14、d2 1、d2 8采用Elisa法测定其血清TNFα、IL - 10浓度并计算IL - 10 /TNFα比值及当天的APACHEⅡ和SOFA评分 ,至脓毒症消失。结果 :4 8例脓毒症患儿中 ,18例死亡 ,30例存活。血清TNFα、IL - 10水平及IL - 10 /TNFα比值与APACHEⅡ或SOFA评分无相关性 (P >0 0 5 ) ;死亡组血清IL- 10水平及IL - 10 /TNFα比值均明显高于存活组 (P <0 0 5 ) ,但死亡组与存活组之间的d1、d3及最后1d血清TNFα、IL - 10水平及IL - 10 /TNFα比值差异无显著意义 (P >0 0 5 )。结论 :血清IL - 10水平或IL - 10 /TNFα比值高的脓毒症患儿 ,预后差。
Objective: To monitor the changes of serum TNFα、IL-10 and IL-10/ TNFα ratio in sepsis of neonates and evaluate their immunological condition ,relationship between severity of illness, prognosis and serum TNFα、IL-10 and IL-10/ TNFα ratio .Method:Patients APACHEⅡscore, SOFA score, and TNFα、IL-10 and IL-10/ TNFα ratio of serum were determined in the 1st,3rd,5th,7th,14th,21th and 28th days after the diagnosis of sepsis was made. Result: At the end of this evaluation,30 cases survived and 18 cases died. There were no relationship between TNFα、IL-10 and IL-10/ TNFα ratio of serum and the severity of illness or prognosis(P>0.05). IL-10 and IL-10/ TNFα ratio of serum in the dead were significantly higher than that in the survivors(p<0.05),but the 1st,3rd,the last day measurements of serum TNFα、IL-10 and IL-10/ TNFα ratio in the survivors were same as the corresponding results in the dead(p<0.05).Conclusion: The sepsis neonates with high IL-10 and IL-10/ TNFα ratio of serum have a poor prognosis.
出处
《河北医学》
CAS
2004年第10期872-874,共3页
Hebei Medicine
