摘要
目的 :总结冷循环射频消融术联合经导管肝动脉栓塞化疗术 (transcatheterarterialchemoemboliza tion ,TACE)治疗不宜手术切除肝癌的效果和经验。方法 :采用冷循环射频消融术联合TACE治疗手术不宜切除肝癌 31例 (共 4 4个肿瘤结节 )。结果 :肝功能指标中除术后ALT水平较术前明显升高 (P <0 .0 5 )外 ,其他各项指标均无统计学差异 (各P >0 .0 5 )。术中、术后发生窦性心动过缓、高钾血症及急性胰腺炎各 1例 (3/2 9 ,10 .3% ) ,无手术死亡。术后CT检查显示 :4 4个肿瘤结节中 ,37个病灶 (占 84 .1% )为完全坏死 ,5个病灶(占 11.4 % )为不完全坏死 ,2个 (占 4 .5 % )病灶为部分坏死。随访 3～ 2 8个月 ,术后 1年肿瘤复发率为 2 0 .7% (6 / 2 9) ,1年生存率为 89.7% (2 3/ 2 9)。结论 :冷循环射频消融联合TACE治疗不宜手术切除的肝癌是安全有效的。
Objective:To summarize the results and experience of combining radiofrequency(RF) ablation with cooled-tip electrodes and transcatheter arterial chemoembolization(TACE) for the treatment of patients with unresectable liver cancer.Methods:Thirty-one patients(totally with 44 tumors) with unresectable liver cancers underwent the treatment of combination of radiofrequency ablation with cooled-tip electrodes and TACE.Results:Among parameters of liver function,the levels of glutamic-alanine transaminase increased significantly after RF(P<0.05),and no important changes in levels of other indexes were observed(all P>0.05). There was no operation death in this study,and three minor complications occurred in three patients(3/29,10.3%) during or after operations:sinus bradycardia,hyperkalemia and acute pancreatitis. CT scan obtained after RF ablation showed that complete necrosis was achieved in 37 tumors(84.1%),nearly complete necrosis in 5 tumors(11.4%) and partial necrosis in 2 tumors(4.5%) in 44 tumors nodules. All patients were followed-up ranging from 3 months to 28 months. The tumor recurrent rate within one year was 20.7%(6/29),and 1-year survival rate was 89.7%(23/29).Conclusion:The therapy combining RF ablation with cooled-tip electrodes and TACE for patients with unresectable liver cancer is effective and safe.
出处
《肝胆胰外科杂志》
CAS
2004年第3期178-181,共4页
Journal of Hepatopancreatobiliary Surgery
关键词
肝肿瘤
射频消融术
肝动脉栓塞化疗
liver neoplasms
radiofrequency ablation
transcatheter arterial chemoembolization
