摘要
报告1例恶性萎缩性丘疹病伴肠穿孔。患者男,23岁。躯干、四肢反复出现丘疹2年,间断性腹部胀痛3个月。皮损组织病理检查示:表皮变薄,角化过度,表皮突消失,真皮灶性坏死及皮肤附属器减少,纤维组织增生伴胶原化,小血管周围可见灶状淋巴细胞浸润。小肠病变组织病理检查示:固有层及黏膜下血管淤血,血管内皮增生,血管周围炎性细胞浸润,部分血管呈血栓性闭塞,部分血管壁退行性改变,肠壁全层大量淋巴细胞及中性粒细胞浸润。经双嘧达莫(潘生丁)、雷公藤多苷、叶酸、维生素B10等药物治疗无效,最终死亡。
A 23-year-old male patient presented with recurrent papulae on his trunk and limbs for 2 years and intermittent abdominal pain for 3 months. The lesion biopsy showed that epidermal atrophy and hyperkeratosis, skin appendages lessened and dermal hyperplasia and collagenization. Small intestine biopsy showed acute and chronic inflammation of the mucous membrane, blood stagnation in lamina propria and submucous blood vessels, vascular endothelial cell proliferation, vasculitis and perivasculitis, thrombotic obliteration of some vessels, diffused lymphocyte and neutrophil infiltration. The patient had no response to the combined therapy of persantine, multiglycosidorum Tripterygii, folic acid and vitamin B12 and died at last.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2004年第10期611-613,共3页
Journal of Clinical Dermatology
关键词
萎缩性丘疹病
恶性
肠穿孔
atrophic papulosis, malignant
intestinal perforation
