摘要
目的 :通过调查急性心肌梗死 (AMI)患者血浆白细胞介素 - 6 (IL - 6 ) ,C -反应蛋白 (CRP)与患者抑郁程度 (HADS -D评分 )之间的关系 ,探讨炎症反应在“后心梗抑郁”的产生及其在冠心病预示机制中的作用。方法 :5 8例AMI患者于入院时抽取外周静脉血 ,检测其发病 36小时以内血浆IL - 6、CRP水平 ;患者入院七天内完成标准化问卷调查表《医院情绪调查表—抑郁分表》(HADS -D)并计分 ,记录年龄、性别、冠心病危险因子及相关临床数据 ,包括心功能分级 (NYHA)、左室射血分数 (LVEF)、冠脉造影结果等。结果 :抑郁组AMI患者血浆IL - 6、CRP的水平显著高于非抑郁组 (0 .93± 0 .6 4vs 0 .4 8± 0 .37ng/L ,P <0 .0 5及 0 .96± 0 .4 1vs0 .4 7± 0 .2 6mg/dl,P <0 .0 5 )。患者的HADS -D评分、IL - 6水平与冠脉造影结果显示的动脉粥样硬化病变程度及LVEF不相关。结论 :AMI患者合并“后心梗抑郁”与患者体内炎性反应活跃有关。
Objective To explore the relationship between the presence and severity of post-MI depression and the increased inflammatory activity, as marked by the serum levels of interleukin-6(IL-6) and C-reactive protein (CRP) after myocardial infarction. Methods Serum IL-6 and CRP levels were measured in 58 AMI patients within 36 hours after onset of event. Depression was evaluated by self-reporting standardized questionnaire, using a validated Chinese version of Hospiatla Anxiety and Depression Scale (HADS)-Depression Subscale (7 items) within 7 days. Demographic and medical data including LVEF, NYHA cardiac function grading, atherosclerosis severity shown from angiography as well as cardiac risk factors were recorded. Results Serum levels of IL-6 and CRP were higher in depressive AMI patients than those in non-depressive ones (0.93±0.64 vs 0.48±0.37ng/L, P <0.05 and 0.96±0.41 vs 0.47±0.26mg/dL, P <0.05). Neither levels of IL-6 nor HADS-D scores were found to be correlated to the severity of atherosclerosis shown in angiography. Conclusion Presence and severity of post-MI depression is associated with increased activity of inflammation in patients after myocardial infarction.
出处
《放射免疫学杂志》
CAS
2004年第4期262-264,共3页
Journal of Radioimmanology
