摘要
目的 :检测溃疡性结肠炎患者 (UC)的组织及血清中白细胞介素 - 8(IL - 8)的含量 ,了解其在溃疡性结肠炎发病中的作用。方法 :收集 34例经内镜检查证实的UC患者结肠黏膜组织和血清标本 ,采用放射免疫分析检测IL - 8的含量。并与正常对照组进行比较。结果 :UC组中病变局限组血清和组织中IL - 8含量分别为(1 81 5 7± 2 6 6 7)ng/L、(71 4 80± 1 84 30 )pg/mg病变广泛组血清和组织中IL - 8含量分别为 (2 1 7 91± 5 8 1 1 )ng/L、(1 0 5 6 5 0± 30 8 1 0 )pg/mg与 32例正常对照组患者比较有显著性差异。结论 :UC患者的组织和血清中IL - 8含量明显升高 ,随着病变范围的扩大和病变程度的增加 。
Objective To study the role played by IL-6 in the pathogenesis of ulcerative colitis by examining its serum and tissue contents. Methods Biopsy specimens of chronic lesions were obtained through colonoscopy in 34 patients with ulcerative colitis. Tissue and serum contents of IL-8 were determined with RIA (also in 32 controls). Results In patients with localized colitis ( n=19 ), the serum and tissue contents of IL-8 were 181.57±26.67ng/L、 714.80±184.30pg/mg respectively. In patients with extensive disease, the corresponding figures were 217.91±58.11ng/L and 1056.50±308.10pg/mg. All of them were significantly higher than those in the controls ( P <0.05). Conclusion The serum and tissue contents of IL-6 were significantly higher in patients with ulcerative colitis than those in the controls; the increase was progressively more prominent with the advancement of the disease process.
出处
《放射免疫学杂志》
CAS
2004年第4期274-275,共2页
Journal of Radioimmanology
