摘要
褪黑素（melatonin，MEL）主要由松果腺分泌，它是一种吲哚类激素，其功能之一能抑制下丘脑的促性腺释放激素和垂体前叶的促性腺激素。本工作利用原位杂交方法，观察了MEL对促甲状腺释放激素（thyrotropinreleasinghormone，TRH）兴奋垂体前叶激素-催乳素（prolactin，PRL）表达的影响。结果表明，在一定浓度范围内，MEL不但可抑制TRH刺激PRL基因表达的效应，还可直接抑制垂体前叶细胞PRL基因的表达。这为进一步探讨在体条件下MEL对PRL合成与分泌的调节，提供了实验依据。
and Methods This work was to investigate whether melatonin(MEL) plays a role in the gene expression of prolactin(PRL), by the Method of in situ hybridyzation. Results Our results indicated that, at a higher concentration, MEL not only inhibits TRH (thyrotropin releasing hormone) stimulating PRL gene expression of anterior pituitary cell in newborn rat, but also exerts a direct inhibitory effect on PRL gene expression in vitro. Conclusion These results suggest that MEL may be a regulator of PRL synthesis and secreting in vivo.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1997年第6期430-435,共6页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金!39470276
