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锰离子增强磁共振成像在大鼠嗅球神经传导及早期确定脑缺血中心研究中的应用 被引量：4

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摘要 以二价锰离子(Mn2+)为示踪剂的磁共振成像是近年来发展起来的可在体、动态地追踪神经传导通路和研究大脑功能的一种脑成像新技术. 利用这项技术对静息状态下Mn2+在大鼠嗅球层状结构间的传递过程以及大鼠急性脑缺血模型中的钙离子(Ca2+)超载过程进行了研究, 得到了大鼠嗅球高空间分辨率的层状结构图像, 并测得静息状态下Mn2+在嗅球层状结构间的表观传递速率大约为0.2 mm/h. 急性大鼠脑缺血研究结果表明, 缺血早期存在Mn2+沉积区域的面积(代表缺血过程中存在Ca2+超载的区域)仅为扩散加权图像中的高信号区域面积的(5515)%, 提示以Mn2+为示踪剂的磁共振成像比常用的扩散加权成像能更为准确地早期确定缺血中心区域.
作者 方可 李英霞 刘华 廖维靖 雷皓
机构地区 中国科学院武汉物理与数学研究所 武汉大学中南医院
出处 《科学通报》 EI CAS CSCD 北大核心 2004年第16期1627-1633,共7页 Chinese Science Bulletin
关键词 磁共振成像 脑缺血 二价锰离子 钙离子 嗅球 神经传导 急性缺血模型
分类号 R445.2 [医药卫生—影像医学与核医学] R338 [医药卫生—人体生理学]
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参考文献25

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同被引文献49

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科学通报
2004年 第16期

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