摘要
目的:观察新生戒毒胶囊对海洛因成瘾小白鼠戒断作用。方法:将100只小白鼠随机分为5组,测量跳跃次数、跳跃反应数及体质量变化并比较各组差异有无显著性意义。结果:新生戒毒胶囊各剂量组与福康片对照组的跳跃次数和跳跃百分率显著低于生理盐水组(P<0.001),新生戒毒胶囊大剂量组跳跃次数和跳跃百分率(2.7±2.1,10%)显著低于福康片组(5.8±2.9,30%,P<0.001和P<0.05)。新生戒毒胶囊大、小剂量组之间跳跃次数和跳跃百分率其值分别为2.7±2.1,10%;6.5±3.8,35%)差异有显著性意义(P<0.001)。新生戒毒胶囊各剂量组与福康片对照组的体质量改变,显著低于生理盐水组(P<0.01～0.05),新生戒毒胶囊大剂量组犤(-0.09±0.17犦)显著低于福康片对照组犤(-0.30±0.28)g犦,(P<0.0001)。结论:新生戒毒胶囊对海洛因成瘾小白鼠急性戒断时跳跃次数、跳跃百分率和体质量改变的对抗作用有一定的量效关系。
AIM:To study the influence of the xinsheng jiedu capsule on the mice addicted to heroin. METHODS:Totally 100 mice were randomly divided into 5 groups,then,jumping times,jumping reaction times and changes of body mass were measured and differences among the groups were compared. RESULTS:The jumping times and percent in the high,middle and low dosage xinsheng jiedu capsule groups and fukang tablet group were significantly lower than those in the saline group(P< 0.001);and the jumping times and percent in the high dosage xinsheng jiedu capsule group(2.7±2.1,10%)were significantly lower than those in the fukang tablet group(5.8±2.9,30%)(P< 0.001,P< 0.05),and there were significant differences in the jumping times and percent between the high(2.7±2.1,10%) and low dosage(6.5±3.8, 35%)xinsheng jiedu capsule groups(P< 0.001).The changes of body mass in the high,middle and low dosage xinsheng jiedu capsule groups and fukang tablet group were significantly lower than that in the saline group(P< 0.01 to 0.05),and the chang in the high dosage xinsheng jiedu capsule group[(-0.09±0.17) g] was significantly lower than that in the fukang tablet group[(-0.30±0.26) g](P< 0.000 1). CONCLUSION:The xinsheng jiedu capsule has the quantity effect relation with the jump times,jump percent and changes of body mass in mice addicted to heroin.
出处
《中国临床康复》
CSCD
2004年第27期5876-5877,共2页
Chinese Journal of Clinical Rehabilitation
