摘要
背景:对放射线单一危害的影响研究很多,但烟、茶和放射线联合作用因素对实验动物体质量及白细胞影响的研究文献报道较少。目的:观察吸烟、饮茶和放射线单独或联合作用对小鼠体质量及外周血白细胞计数的影响。设计:随机双盲法观察。地点和材料:取健康小鼠64只,在滨州医学院毒理研究室作观察研究。干预:取健康小白鼠64只,分成8组,7组小鼠单独或联合给予吸烟7d,饮茶7d和放射线照射(2Gy),1组为空白对照组,观察小鼠体质量、外周血白细胞计数的变化。主要观察指标:实验7d后的小鼠体质量增长情况及实验末时外周血白细胞计数变化。结果:吸烟组小鼠体质量增长犤(-1.63±1.51)g犦低于空白对照组犤(0.50±1.65)g犦(t=2.693,P<0.05),放射组小鼠体质量增长犤(-2.25±1.20)g犦低于空白对照组(t=3.821,P<0.01),放射组小鼠白细胞计数犤(4.28±1.71)×109L-1犦低于空白对照组犤(7.74±1.97)×109L-1犦(t=3.761,P<0.01)。结论:吸烟和放射线均可抑制小鼠体质量增长,放射线可使小鼠外周血白细胞减少。烟茶对放射线引起的小鼠体质量和血液白细胞数下降无明显干预作用。
BACKGROUND:There were a lot of studies on the effects of hazards of single radioactive rays,but very few which reported the effects of joint active factors,such as smoking,tea drinking and radioactive on the experimental animal's mass and white blood cell(WBC). OBJECTIVE:To observe the effects of smoking,tea drinking and radioactive rays on mouse's mass and WBC counting. DESIGN:Randomized and double blind observation. SETTING and MATERIALS:A total of 64 healthy mice were studied in the Lab of Toxicology in Binzhou Medical College. INTERVENTIONS:A total of 64 healthy mice were divided into 8 groups.Mice of 7 groups were given separately or combinedly smoking for 7 days,tea drinking for 7 days and radioactive rays with 2 Gy respectively.In the blank control group,mass and white blood cell of the eight mice WBC counting were observed. MAIN OUTCOME MEASURES:Mass increasing after 7 days and WBC counting of mice at the end of experiment were observed. RESULTS:The increasing mass of smoking group[(-1.63±1.51) g] was lower than that of blank control group[(0.50±1.65) g] (t=2.693,P< 0.05),and that of irradiation group[(-2.25±1.20) g] was lower than that of blank control group(t=3.821,P< 0.01).WBC counting in irradiation group[(4.28±1.71)×109 L-1]was lower than that of the blank control group[(7.74±1.97)×109 L-1](t=3.761,P< 0.01). CONCLUSION:Smoking can inhibit mouse's mass.Radioactive rays can decrease mouse's mass and WBC number.Smoking and tea drinking don't have any obvious intervention in the decrease of mouse's mass and WBC.
出处
《中国临床康复》
CSCD
2004年第27期5990-5991,共2页
Chinese Journal of Clinical Rehabilitation
