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N-茄呢基谷氨酰胺类化合物的合成 被引量:8

Synthesis of N-Solanesylglutamide Derivatives
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摘要 在N,N 二环己基碳二酰亚胺存在下,N 苯甲酰 Nα 茄呢基 L 谷氨酰胺酸和N 羟基琥珀酰亚胺反应制成活化酯,然后分别与胺或者氨基酸甲酯盐酸盐反应制得3种新N 茄呢基谷氨酰胺类化合物.这些化合物的结构经IR、1HNMR、MS和元素分析确证. Three new compounds were first synthesized by the reaction of N-benzoyl-N~α-solanesyl glutaminic acid with different amines or amino acid ester hydrochloride by the method of the activated N-hydroxysuccinimide ester in the presence of N, N-dicyclohexylcarbodiimide. Their structures were confirmed by IR, ()~1H NMR,MS and elemental analyses.
出处 《化学研究》 CAS 2004年第3期27-29,共3页 Chemical Research
基金 河南省重点科技攻关(O323024000) 河南大学重点学科资助项目.
关键词 N-茄呢基谷氨酰胺类化合物 合成 氨基酸 茄呢醇 药物中间体 solanesylamine N-benzoyl-N~α-solanesyl glutaminic acid N-benzoyl-N~α-solanesylglutamide
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