期刊文献+

2型糖尿病伴感染患者细胞免疫和体液免疫的研究 被引量:18

The Study of Cell Immunity and Humoral Immunity in Type 2 Diabetic Mellitus Patients Complicating With Infections
下载PDF
导出
摘要 目的 :探讨 2型糖尿病伴感染患者血液中细胞免疫和体液免疫的变化。方法 :采用流式细胞术和速率散射免疫比浊法测定 2 2例糖尿病伴感染患者血液细胞免疫参数 (CD3、CD4、CD4/CD8、B细胞、NK细胞 )和血清免疫球蛋白 (IgG、IgA、IgM )、补体 (C3、C4)等体液免疫参数 ,并与 40例 2型糖尿病不伴感染患者及 46例健康体检者比较。结果 :2型糖尿病无论是否伴有感染 ,与健康对照组比较 ,CD4、CD4/CD8、B细胞、NK细胞显著性减低 (P <0 .0 1) ,IgA、IgM、C3显著升高 (P <0 .0 1) ;伴感染组与不伴感染组比较 ,CD3、CD4/CD8、B细胞、NK细胞及C3、C4均显著增高。结论 :2型糖尿病患者无论是否伴有感染 ,机体内细胞免疫和体液免疫功能均已减低 。 Objective To investigate the change s of cell immunity and fluid immunity in type 2 diabetic mellitus patients complic ating with infections. Methods We have analyzed T cell sub sets(CD3?CD4?CD8),CD4 /CD8,B-cells,nature killer cells (NK) and immunoglobu lins (IgG?IgIgM),complements(C3?C4) in 22 diabetic mellitus patients compli cating with infections, compared with those of 40 diabetic mellitus patients wit hout infections, and 46 normal controls. Results Type 2 di abetic mellitus patients with and without infections,CD4,CD4/CD8,B,NK are signif icantly lower and IgA,IgM,C3,C4 significantly higher than those of normal contro ls (p<0.01);meanwhile, CD3,B,NK,C3,C4 in type 2 diabetic mellitus patients with infections are significantly higher than those of type 2 diabetic mellitus patie nts without infections. Conclusion These results indicated that there were impaired immune function in type 2 diabetic mellitus patients w ith and without infections ; after infections,T cell subsets,B-cells,nature ki ller cells (NK) and immunoglobulins were increased.
出处 《郧阳医学院学报》 2003年第5期275-277,共3页 Journal of Yunyang Medical College
关键词 2型糖尿病 细胞免疫 体液免疫 免疫球蛋白 补体 流式细胞术 速率散射免疫比浊法 diabetes mellitus cells immunity humoral immunity complement
  • 相关文献

参考文献6

二级参考文献19

  • 1李明龙,陈凌,徐德凤.非胰岛素依赖型糖尿病患者的免疫功能研究[J].上海免疫学杂志,1996,16(1):26-28. 被引量:40
  • 2吉琼梅.Ⅱ型糖尿病患者红细胞的生化改变[J].国外医学(生理病理科学与临床分册),1996,16(2):107-109. 被引量:8
  • 3Loots MA,Lamme EN,Zeegelaar J,et al Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds[J]. J Invest Dermatol,1998,111(5): 850-857.
  • 4essman AN,Sapico FL. Infections in the diabetic patient: the role of immune dysfunction and pathogen virulence factors[J].J Diabetes Complications,1992,6(4): 258-262.
  • 5Boulton A. The diabetic foot. In: Tattersall RB,Gale EA(ed). Diabetes Clinical Management[J]. N.Y.:Churchill Livingstone,1990,293-306.
  • 6Perschel WT,Langefeld TW,Federlin K. Susceptibity to infections in diabetes-effects on metabolism[J]. Immun-Infekt,1995,23(6): 196-200.
  • 7Jensen LS,Hokland M,Nielsen HJ.A randomized controlled study of the effect of bedside leucocyte depletion on the immunosuppressive effect of whole blood transfusion in patients undergoing elective colorectal surgery[J]. Br. J Surg,1996,83:973~977.
  • 8West NJ. Systemic antimicrobial treatment of foot infections in diabetic patients. Am J[J].Health Syst Pharm,1995,1199-1207.
  • 9王德勋.糖尿病人感染时免疫功能变化的临床意义[J].中国实用外科杂志,1996,16(10):595-595.
  • 10Egychi K, Yagame M, Suzuki D, et al. Signiflcance of high level of serum IgA andIgAclass circulating immune complexes (lgA-CIC) in patients with non-insulin-dependentdiabetes mellitus. J Diabetes Complications, 1995,9( 1 ): 42.

共引文献718

同被引文献191

引证文献18

二级引证文献96

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部