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新型抗炎及免疫调节药来氟米特 被引量:1

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摘要 来氟米特是新型的具有抗炎和免疫调节作用的异噁唑类衍生物。对许多自身免疫性疾病,包括系统性虹斑狼疮、过敏性脑脊髓炎、肾炎、关节炎动物模型以及人体类风湿性关节炎都有较好的预防和治疗作用,还能有效地延长移植物的存活时间。该药作用机理不同于一般的抗炎药及免疫抑制剂,可能是通过抑制、B淋巴细胞产生抗体,拮抗细胞因子作用,抑制炎症介质产生、细胞增殖与酪氨酸激酶而起作用的。
出处 《国外医学(药学分册)》 1993年第6期336-339,共4页 Foreign Medical Sciences(Section of Pharmarcy)
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  • 1R. R. Bartlett,M. Dimitrijevic,T. Mattar,T. Zielinski,T. Germann,E. Rüde,G. H. Thoenes,C. C. A. Küchle,H. -U. Schorlemmer,E. Bremer,A. Finnegan,R. Schleyerbach. Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection[J] 1991,Agents and Actions(1-2):10~21
  • 2T. Ogawa,M. Inazu,K. Gotoh,S. Hayashi. Effects of leflunomide on glomerulonephritis induced by antibasement membrane antibody in rats[J] 1990,Agents and Actions(3-4):321~328
  • 3P. Hambleton,S. McMahon. Drug actions on delayed-type hypersensitivity in rats with developing and established adjuvant arthritis[J] 1990,Agents and Actions(3-4):328~332
  • 4R. D. Pasternak,N. S. Wadopian,R. N. Wright,P. Siminoff,J. A. Gylys,J. P. Buyniski. Disease modifying activity of HWA 486 in rat adjuvant-induced arthritis[J] 1987,Agents and Actions(3-4):241~243
  • 5S. Popovic,R. R. Bartlett. The use of the murine chronic graft Vs host (CGVH) disease, a model for systemic lupus erythematosus (SLE), for drug discovery[J] 1987,Agents and Actions(3-4):284~286
  • 6S. Popovic,R. R. Bartlett. Disease modifying activity of HWA 486 on the development of SLE in MRL/1-mice[J] 1986,Agents and Actions(5-6):313~314

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