摘要
目的研究整合素α5β1在大肠癌及癌旁组织中的表达与肿瘤细胞分化、转移等生物学行为的关系。方法用免疫组化EV二步法检测81例大肠癌及相应癌旁组织石蜡标本整合素α5β1的表达情况。结果在81例大肠癌组织中整合素α5β1表达量与相应的癌旁组织相比差异有显著性(P<0.05),癌旁组织中整合素α5β1的表达量明显降低。低分化大肠癌组织中整合素α5β1的表达量高于高分化大肠癌,有显著性差异(P<0.05)。整合素α5β1在大肠癌的表达与是否有淋巴结转移无相关性(P>0.05)。结论整合素α5β1的表达与大肠癌癌变及癌细胞的分化关系较密切,与癌组织发生淋巴结转移的关系不明显。整合素α5β1的表达量可作为大肠癌发生、发展过程中的一种较有价值的病理学指标。
Objective To study the correlation between the expression of integrin α 5 β 1 in colorectal carcinomas and the differentiation and metastasis of the tumor cells. Methods The expression levels of integrin α 5 β 1 were detected immunohisto- chemically in 81 pairs of cancerous and non-cancerous tissues of patients with colorectal cancer. Results The expression of integrin α 5 β 1 was significantly higher in the samples of colorectal carcinomas, than in non-cancerous tissues (P<0.05). Lower expression levels were detected in moderately or well differentiated colorectal carcinomas than in poorly differentiated ones (P<0.05). No significant relation was noted between the expression of integrin α 5 β 1 and lymph node metastasis of the colorectal carcinomas (P>0.05). Conclusionα 5 β 1 expression is significantly associated with the carcinogenesis and differen- tiation of colorectal carcinomas, but not with their lymph node metastasis, and the expression level might be used as a valuable pathological indicator for the carcinogenesis and progression of colorectal carcinomas.
出处
《第一军医大学学报》
CSCD
北大核心
2003年第8期806-808,共3页
Journal of First Military Medical University
基金
国家自然科学基金(30170423)~~
