摘要
目的 探讨用胶体次CBS或PPI联合克拉霉素,阿莫西林治疗儿童HP相关性胃炎,与其他治疗方案的疗效。方法 180例4～12岁患儿经胃镜检查确诊为幽门螺杆菌相关性胃炎,随机分为A、B、C三组。A组用胶体次枸橼酸铋联合克拉霉素和阿莫西林。B组用奥美拉唑联合克拉霉素和阿莫西林。C组用安慰剂,治疗1周。结果 (1)治疗后HP有效率A组83.3％,B组96.7％,C组26.7％。三个方案组对HP有效率差异有非常显著性,X^2=77.35,P<0.001。(2)治疗后HP根除率A组61.7％,B组88.3％,C组10％。三个方案对HP根除率差异有非常显著性,X^2=76.47,P<0.001。(3)各组比较,B组最好,C组最差。结论 以铋剂或PPI为主联合克拉霉素和阿莫西林治疗儿童HP相关性胃炎,具有疗效高、副作用小和HP根除率高等优点。
Objective To evaluate the therapeutic effect of different programs consisted of colloidal bismuth subsitrate (CBS) or PPI plus clarithromycin (CLA) and amoxicillin on Helicohacter pylori (HP) - related gastritis in children. Methods 180 children (4 to 12 years old) with gastroscopically confirmed Hp- related gastritis were divided into 3 groups (A. B. C) at random. Group A were given CBS 9mg/(kg·d) ,CLA 15rng/(kg·d) and arnoxilin 30mg/(kg·d), Group B were given omeprazole 0. 6mg/(kg·d), CLA 15mg/(kg·d) and amoxillin; Group C were given placebo, for one week. Results (1) The effective rates of HP were as follows: Group A: 83. 3%; Group B: 96.7%; Group C: 26. 7% . The differences were highly significant (X2 = 77. 35, P<0. 001) (2)The eradication rates of HP were as follow: Groups A: 61.7%; Groups B: 88.3%; Groups C: 10%. The differences were highly significant (X2 = 76.47, P<0.001). (3) The comparison among the 3 groups showed that Ggroup C had poorest effect while Group B had the highest eradication rate. (4) The side effects (diarrhea, vomiting, and nausea) were mild. Their occurrence rate was the lowest in Group B, followed by Group A. The symptoms caused by the side effects disappeared when the medication was completed. Conclusion CBS or PP1 plus C'LA and amoxicillin on HP related gastritis are highly effective, with low dose and high eradication rates.
出处
《菏泽医学专科学校学报》
2003年第4期33-34,共2页
Journal of Heze Medical College
