摘要
目的 :探讨艾司洛尔复合丙泊酚预防气管插管引起心血管反应的合理用量。方法 :60例全麻行非心脏手术的病人随机被分为3组。A组为对照组 ,静脉注射生理盐水10ml ,B组为艾司洛尔0.5mg·kg-1静注。C组为艾司洛尔1.0mg·kg-1静注。静注丙泊酚和维库溴铵诱导气管内插管。机械通气后呼气末二氧化碳分压 (PETCO2)维持在30～40mmHg。监测记录插管后1、3、5、10分钟收缩压 (SP)、舒张压 (DP)、心率 (HR) ;并抽取血标本用高压液相色谱仪测血浆中去甲肾上腺素 (NE)、肾上腺素 (E)和多巴胺 (DA)浓度。结果 :A组插管后1分钟时血压、心率显著升高 (P<0.01或0.05) ;B组插管后3、5及10分钟时血压、心率显著降低 (P<0.01或0.05) ;3及5分时去甲肾上腺素及肾上腺素水平显著升高 (P<0.01或0.05)。C组插管后心率、血压、去甲肾上腺素与肾上腺素水平显著降低 (P<0.01或0.05) ,与B组比较 ,插管后1和3分钟时肾上腺素水平显著降低 (P<0.01)。结论 :艾司洛尔1.
Objective:To assess the ideal dose of esmolol versus propofol for preventing cardiovascular responses to laryngoscopy.Methods:Sixty adult ASAⅠ-Ⅱpatients scheduled for noncardiac surgical procedures under general anesthesia were randomly divided into three groups.Group A received normal saline10ml intravenously,group B esmolol0.5mg·kg -1 and group C esmolol1.0mg·kg -1 given intraˉvenously over10seconds.After artificial ventilation was started and PETCO 2 was maintained between30～40mmHg.1、3、5and10min after inˉtubation SP,DP and HR were checked and recorded.Blood samples were taken1,3,and5min after intubation.10min after intubation inhalation of isoflurane,nitrous oxide and oxygen was started for maintenance of anesthesia.Results:There were no statistically significant differences in sex,age and body weight among the three groups.In group A,HR,SP,DP and RPP increased significantly at1,3min after EIP<0.01.SP,DP and RPP decreased significantly at3and5min after EI P<0.05in group B%.In group C SBP,DBP and RPP at1,3,5and10min after EI were significantly lower than baseline values.NE and E levels increased significantly at3and5min after EI in group A,but decreased significantly at1,3and5min after EI in group C.Conclusions:Esmolol1.0mg·kg -1 may attenuate catecholamine response to EI without obvious depression of BP and HR.
出处
《现代医药卫生》
2004年第17期1722-1723,共2页
Journal of Modern Medicine & Health
