摘要
目的 探讨环氧合酶 - 2 (COX - 2 )在宫颈癌中的表达 ,及其与血管内皮生长因子 (VEGF)表达和肿瘤微血管密度 (MVD)的关系。方法 应用免疫组化法检测 5 4例宫颈癌中COX - 2、VEGF的表达和MVD值 ,并以 1 0例宫颈CIN和 1 0例正常宫颈上皮为对照组。结果 宫颈癌中COX - 2阳性表达率分别为Ⅰ期5 6 7%、Ⅱ期为 6 6 7%、Ⅲ期 77 8%。VEGF在宫颈癌中阳性表达率分别为Ⅰ期 76 7%、Ⅱ期 80 0 % ,Ⅲ期88 9%。COX - 2在宫颈癌Ⅰ、Ⅱ、Ⅲ期间差异无显著性 (P >0 0 5 )。VEGF宫颈癌Ⅰ、Ⅱ期间差异无显著性 (P>0 0 5 ) ,Ⅰ期与Ⅲ期之间差异有显著性 (P <0 0 5 )。COX - 2、VEGF与MVD的表达呈正相关 ,而与不同的病理分级无明显相关性 (P >0 0 5 )。结论 VEGF、COX - 2、MVD在宫颈癌的发生、发展过程中起着重要作用 ,VEGF、COX - 2、MVD值可作为检测指标 ,为宫颈癌的诊断。
Objective To examine the expression of cyclooxygase-2 (COX-2) in cervical carcinoma,and to reveal its relationship with the microvessel density (MVD) and vascular endothelial growth factor (VEGF).Methods The expressions of COX-2 and VEGF,as well as the MVD,were detected immunohistochemically in 54 patients with cervical cancer.Ten cervical intraepithelial neoplasia (CIN) and 10 normal cervixes served as control group.Results The positive rates of COX-2 were 56 7%,66 7% and 77 8% in cervical cancer stage Ⅰ,Ⅱ and Ⅲ,respectively.The positive rates of VEGF were 76 7%,81 3% and 92% in stage Ⅰ,Ⅱ and Ⅲ,respectively.There was no significant difference of COX-2 expression among the stages ( P> 0 05).Significant difference of VEGF between stage Ⅰ and Ⅲ ( P< 0 05) was observed,yet no difference between stage Ⅰ and Ⅱ ( P> 0 05).The expressions of VEGF and COX-2 were positively related to MVD,while not related to pathological differentiation ( P< 0 05).Conclusions VEGF,COX-2 and MVD play very important roles in the tumorigenesis and the development of cervical carcinoma,so they can be used as indexes of cervical carcinomas for diagnosis,clinical staging and therapy.
出处
《中国妇产科临床杂志》
2004年第3期208-210,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
