摘要
目的 探讨碘生物暴露水平和甲状腺功能减退症 (甲减 )之间的关系。方法 采用单因素和多因素方法对轻度碘缺乏 ( 110 3人 )、碘超足量 ( 15 84人 )、碘过量 ( 10 74人 ) 3个碘生物暴露水平地区 14岁以上成年人 ( 376 1人 )的流行病学调查结果进行分析。结果 单因素分析结果显示 ,轻度碘缺乏、碘超足量和碘过量 3个不同碘生物暴露水平地区临床甲减患病率 ( 0 2 7% ,0 95 %和1 96 % )和亚临床甲减患病率 ( 0 91% ,2 90 %和 6 0 5 % )差异有显著意义 (P <0 0 1) ;甲状腺过氧化物酶抗体 (TPOAb)阳性者临床甲减和亚临床甲减的患病率 ( 11 85 %和 8 71% )显著高于TPOAb阴性者 ( 0 2 0 %和 2 6 5 % ,P <0 0 1) ;甲状腺球蛋白抗体 (TgAb)阳性和阴性者间临床甲减患病率( 8 10 %和 0 6 8% )及亚临床甲减患病率 ( 7 6 2 %和 2 85 % )差异有显著意义 (P <0 0 1) ;女性临床甲减患病率显著高于男性 ( 1 4 1%对 0 11% ,P <0 0 1) ;35岁以上人群临床甲减患病率高于 35岁以下者 ( 1 4 0 %对 0 6 8% ,P <0 0 5 )。引入上述因素的多元Logistic回归结果显示 ,碘超足量、碘过量是临床甲减 (OR =3 6 96和 9 2 13,P <0 0 5 )和亚临床甲减 (OR =3 172和 6 391,P <0 0 5 )的独立危险因素 ;将碘生物暴露水平?
Objective To assess the relationship between the biological exposure to iodine and hypothyroidism. Methods Logistic regression model was used to analyze the risk factors of hypothyroidism, according to the epidemiologic data of 3761 adults in 3 kinds of rural communities: mild iodine deficiency area (4 natural villages in Panshan County, Liaoning Province), more than adequate iodine (7 natural villages of Zhangwu County, Liaoning Province), and excessive iodine area (2 natural villages of Huanghua City, Hebei Province). Results More than adequate iodine and excessive iodine were independent risk factors of subclinical hypothyroidism( OR =3.172 and 6.391, P <0.05) and overt hypothyroidism( OR =3 696 and 9.213, P <0.05). When interactions of iodine exposure and thyroid peroxidase antibody (TPOAb) or thyroglobulin antibody (TgAb) were included, more than adequate iodine was still a risk factor of subclinical hypothyroidism( OR =2.788, P <0.01), but had no such effect on overt hypothyroidism. Interaction of more than adequate iodine and positive TgAb significantly affected subclinical hypothyroidism and overt hypothyroidism (OR =2.656 and 3.347, P <0.05). Conclusion More than adequate and excessive iodine exposure are independent risk factors of hypothyroidism. The risk of hypothyroidism grows up and thyroid dysfunction becomes more serious with the increasing of the biological exposure to iodine.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2004年第14期1171-1174,共4页
National Medical Journal of China
基金
国家自然科学基金资助项目 (3 9970 3 5 0 )
美国中华医学基金会资助项目(98 688IITD)
