摘要
目的 了解老年糖尿病患者血浆抵抗素的浓度及其与肥胖、胰岛素敏感性、血糖、血脂的关系。 方法 选择 5 1例老年 2型糖尿病患者和 4 2例健康老年人 ,分别分为肥胖组和非肥胖组 ,用竞争性酶联免疫吸附法测定各组空腹血浆抵抗素水平 ,同时检测空腹血糖、空腹胰岛素、血脂、胰岛素敏感指数 ,测量受试对象腰围、臀围、腰臀比。 结果 在对照组和糖尿病组中 ,肥胖组空腹血浆抵抗素水平显著高于非肥胖组 (P <0 0 5 ) ;糖尿病非肥胖组空腹血浆抵抗素水平显著高于对照非肥胖组 (P <0 0 1) ,但与对照肥胖组比较 ,差异无显著性 ;糖尿病肥胖组空腹血浆抵抗素水平显著高于对照肥胖组 (P <0 0 5 )。抵抗素与体质指数呈正相关关系 (r =0 2 5 ,P <0 0 5 ) ,与胰岛素敏感指数及空腹胰岛素呈负相关关系 (r=- 0 32、- 0 35 ,P <0 0 5 )。而抵抗素与空腹血糖、各项血脂指标、年龄、性别及腰臀比之间无明显相关性。 结论 在肥胖发展为糖尿病的过程中 ,抵抗素可能参与了胰岛素抵抗 ,并有可能成为诊断胰岛素抵抗的指标之一。
Objective To find out the relationship between the serum resistin levels and obesity, insulin sensitivity, blood-glucose as well as blood lipid in the elderly with diabetes. Methods Senile patients (51) suffering from type 2 diabetes and non-diabetic controls(42) were selected. Their serum resistin levels after an overnight fasting were measured by competitive ELISA. Other data including fasting blood-glucose, insulin, blood lipid, insulin sensitivity index, waistline, hipline and WHR were measured. Results (1)In non-diabetic controls, fasting resistin level was significantly higher in obese subjects than that in those persons with normal weight (P<0.05). (2)In patients with diabetes, fasting resistin level was higher in obese subjects than that in normal weight person (P<0.05). (3)Non-obese patients with diabetes had high serum resistin than non-obese healthy ones (P<0.01), while their resistin level was not higher than that of non-diabetic obese subjects. The resistin level in the obese patients with diabetes was significantly higher than that of non-diabetic controls (P<0.05). Resistin level showed a positive correlation with BMI (r=0.25, P<0.05), and a negative correlation with ISI (r=-0.32, P<0.05) or FINS (r=-0.35, P<0.05). No correlation between resistin and fasting blood-glucose, blood lipid, age, gender and WHR was found. Conclusions Resistin may play a role in the insulin resistance during the developing of obesity to diabetes. Resistin might be one of the indicators for insulin resistant.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2004年第8期531-533,共3页
Chinese Journal of Geriatrics
